Intravenous calcitriol treatment benefits the homeostasis of CD4+ T cells and attenuates kidney injury in obese mice complicated with polymicrobial sepsis

Yeh, Chiu‐Li; Wu, Jin-Ming; Yang, Po‐Jen; Lee, Po‐Chu; Chen, Kuen‐Yuan; Yeh, Sung‐Ling; Lin∥, Ming–Tsan

doi:10.1016/j.nut.2022.111741

Cited by 5 publications

(2 citation statements)

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“…Vitamin D reduces monocyte TLR expression while triggering hypo-responsiveness to bacterial cell wall components, thereby alleviating sepsis [36]. Concerning adaptive immunity, researchers have found that intravenous calcitriol administration post sepsis modulated the homeostasis of CD4+ T-cell populations associated with alleviating kidney injury induced by sepsis in obese mice [37]. Vitamin D also inhibits human B-cell activation stimulated by pokeweed mitogen [38].…”

Section: Discussionmentioning

confidence: 99%

“…As displayed in Table 5, the primary outcomes showed that the vitamin D supplementation group had lower in-hospital mortality (21.5% vs. 29.7%), as well as 28-day (19.5% vs. 26.7%) and 90-day (23.8% vs. 32.3%) mortality rates. As for the disease severity-related scores, SOFA (6 (4-8) vs. 7 (4-10)) and APS III (54 (43-73) vs. 62 (48-82)) scores were significantly lower in the patients with sepsis supplemented with vitamin D compared to those who did not receive vitamin D. Although the SAPS II score (40 (32-49) vs. 42 (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)) was lower in the vitamin D supplementation group, no statistical differences were found between the two cohorts (p = 0.115). Consistently, there were no significant differences for the LOS in the ICU and hospital between the two groups (p = 0.988 and p = 0.207, respectively).…”

Section: Baseline Characteristics Clinical Outcomes Post Psmmentioning

confidence: 98%

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Vitamin D Supplementation during Intensive Care Unit Stay Is Associated with Improved Outcomes in Critically Ill Patients with Sepsis: A Cohort Study

et al. 2023

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Background: Vitamin D, as a common micronutrient, has been widely used in critically ill patients. However, whether supplementation of vitamin D in adult patients with sepsis can improve their prognosis remains controversial. Methods: Data from the Mart for Intensive Care IV database was used in this retrospective cohort study, and adult patients with sepsis were enrolled. Critically ill patients, admitted to intensive care units (ICUs) between 2008 and 2019 at the Beth Israel Deaconess Medical Center (BIDMC), were divided into the vitamin D supplementation group and non-vitamin D supplementation group. The primary outcomes were defined as all-cause in-hospital, 28-day, and 90-day mortality rates after admission to the ICU. A 1:1 propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and overlap weighting (OW) analyses were used to minimize selection bias and balance the baseline demographic characteristics. Regression and survival analyses were performed to assess the association between vitamin D supplementation and clinical outcomes in patients with sepsis. Results: In total, 3539 patients with sepsis were enrolled as study participants; of these, 315 were supplemented with vitamin D during their ICU stay. In-hospital, 28-day, and 90-day mortality rates were significantly lower in patients with sepsis supplemented with vitamin D. Multivariate regression analysis showed vitamin D supplementation as a potential protective factor for in-hospital mortality with an odds ratio (OR) = 0.70 (0.51–0.96) after adjusting for all confounders. The hazard ratios (HRs) for 28-day and 90-day mortality were 0.65 (0.50–0.85) and 0.70 (0.55–0.90), respectively. The survival analysis showed that the vitamin D supplementation group had a higher survival probability within 28 and 90 days (p-value < 0.05). These results remained relatively stable post PSM, IPTW, and OW. However, we found no evidence that vitamin D supplementation could shorten the length of stay in the ICU or hospital. Conclusions: Vitamin D supplementation during an ICU stay was associated with improved prognosis in patients with sepsis, as evidenced by lower in-hospital, 28-day, and 90-day mortality rates and lower disease severity-related scores, but showed no influence on the length of stay in the hospital or ICU.

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Section: Discussionmentioning

confidence: 99%