Intravenous administration of human umbilical cord blood-mononuclear cells dose-dependently relieve neurologic deficits in rat intracerebral hemorrhage model

Seghatoleslam, Masoumeh; Jalali, Mehdi; Nikravesh, Mohammad Reza; Alamdari, Daryoush Hamidi; Hosseini, Mahmoud; Fazel, Alireza

doi:10.1016/j.aanat.2012.05.002

Cited by 15 publications

(17 citation statements)

References 67 publications

(49 reference statements)

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“…Many stem cell administration routes have been tested, but it remains unclear which is the best option. Findings in ICH model support that cervical vein delivery is inefficient [133] , whereas good outcomes were already observed following stem cell delivery in brain parenchyma [66,111,[113][114][115][116]121,126,[134][135][136][137] , lateral ventricle [120,133] , tail vein [117,119,122,[124][125][126]138,139] , and carotid artery [133,140,141] . However, each one of these alternatives has drawbacks.…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 70%

“…BMSC injection of 1 million cells was more therapeutically effective than half of it [122,122] . UCMCs were also more effective in the highest tested amount (16 million cells), reducing injury area with more success [124] . However, apart from this studies, the most common quantity injected in the tail vein is of 3 million cells, suspended in 1 or 2 mL of saline solution [117,119,124,125] .…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 93%

“…UCMCs were also more effective in the highest tested amount (16 million cells), reducing injury area with more success [124] . However, apart from this studies, the most common quantity injected in the tail vein is of 3 million cells, suspended in 1 or 2 mL of saline solution [117,119,124,125] . The amount of intracerebrally grafted cells varied up to 25 fold among studies [66,113,115,121,136] .…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 93%

“…The same is true to the intensified angiogenesis, presumably due to elevated VEGF release [66,113,122,123] . Hematoma area reduction is also often observed [66,115,119,121,124] , but not always [112][113][114]117] . Likewise, decrement of brain edema volume is a commonly stated benefice [113,125,126] .…”

Section: Stem Cell Therapeutic Effects and Underlying Mechanismsmentioning

confidence: 99%

“…The only studies performed with variations in that parameters used the tail vein route [122,122,124] . BMSC injection of 1 million cells was more therapeutically effective than half of it [122,122] .…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

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Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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Intracerebral hemorrhage (ICH) is a very complex pathology, with many different not fully elucidated etiologies and prognostics. It is the most severe subtype of stroke, with high mortality and morbidity rates. Unfortunately, despite the numerous promising preclinical assays including neuroprotective, anti-hypertensive, and anti-inflammatory drugs, to this moment only symptomatic treatments are available, motivating the search for new alternatives. In this context, stem cell therapy emerged as a promising tool. However, more than a decade has passed, and there is still much to be learned not only about stem cells, but also about ICH itself, and how these two pieces come together. To date, rats have been the most widely used animal model in this research field, and there is much more to be learned from and about them. In this review, we first summarize ICH epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts. Core tip: In this review, we first summarize intracerebral hemorrhage (ICH) epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.Cordeiro MF, Horn AP. Stem cell therapy in intracerebral hemorrhage rat model. World J Stem Cells 2015; 7(3): 618-629

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Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 70%

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 93%

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 93%

Section: Stem Cell Therapeutic Effects and Underlying Mechanismsmentioning

confidence: 99%

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

See 3 more Smart Citations

Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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Cord Blood as a Treatment for Stroke

Willing

Foran

2014

Cellular Therapy for Stroke and CNS Injuries

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Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study

et al. 2017

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This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (2) PTU (received 0.005% PTU in drinking water), (3-5) PTU + NS 0.05%, PTU + NS 0.1%, PTU + NS 0.2% (along with PTU, received 0.05%, 0.1% and 0.2% W/V of N. sativa respectively) and treatment continued until postnatal day 60 (PN 60). The brains of male pups were removed for histological and stereological assessments. N. sativa extract significantly reduced the production of dark neurons and apoptotic cells in different areas of the hippocampus compared to the PTU group. Moreover, it significantly attenuated the effect of hypothyroidism on the volume reduction of the hippocampus. The results of the present study suggested that N. sativa extract has a potential ability to prevent the hippocampal neural damage after inducing hypothyroidism during neonatal and juvenile growth in rats.

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Intravenous administration of human umbilical cord blood-mononuclear cells dose-dependently relieve neurologic deficits in rat intracerebral hemorrhage model

Cited by 15 publications

References 67 publications

Stem cell therapy in intracerebral hemorrhage rat model

Stem cell therapy in intracerebral hemorrhage rat model

Cord Blood as a Treatment for Stroke

Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study

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