Intravascular Pyogenic Granuloma Arising in an Acquired Arteriovenous Malformation: Report of a Case and Review of the Literature

Hung, Chia-Hui; Kuo, Hung-Wen; Chiu, Yao-Kun; Huang, Po‐Han

doi:10.1111/j.1524-4725.2004.30316.x

Cited by 22 publications

(20 citation statements)

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“…These lobules are separated by an edematous fibromyxoid stroma containing collagenous fibers, spindle cells, and mitotic figures. 1,13 Interestingly, the luminal surface of the tumor will also have an endothelial lining. 1 Unlike the implication of the former term, pyogenic granuloma, no inflammatory cells are present within the mass (Fig 3, B).…”

Section: Discussionmentioning

confidence: 99%

“…1,6,10 There are no known associated risk factors; however, some reports suggest these lesions are linked with arteriovenous malformations. [11][12][13] The differential diagnosis characteristically focuses on vascular related pathologies, including deep venous thrombosis, aneurysm, ganglion or other neural lesion, vascular tumor, and papillary endothelial hyperplasia. 1,4,9 With no characteristic clinical features, the diagnosis of intravenous lobular capillary hemangioma relies on imaging studies.…”

Section: Discussionmentioning

confidence: 99%

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Intravenous lobular capillary hemangioma originating in the iliac veins: A case report

Pradhan

Bazan

Salem

et al. 2008

Journal of Vascular Surgery

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Intravenous lobular capillary hemangioma is a rare benign lesion that can mimic other intravascular lesions encountered by vascular surgeons, such as angiosarcoma, papillary endothelial hyperplasia, and deep vein thrombus. These lesions have been described originating in the veins of the head, neck, and upper extremities. To our knowledge, there are no reported cases of intravenous capillary hemangioma arising from within a pelvic vein. We report a case of an elderly woman found to have an extensive intravenous lobular capillary hemangioma originating in the internal iliac vein. She was successfully treated with resection, including the tumor and normal iliac vein. Diagnosis of these lesions can be difficult. We describe the utility of duplex ultrasound and magnetic resonance venography in aiding preoperative diagnosis and surgical planning. The diagnosis is ultimately confirmed with histology that demonstrates multiple capillaries lined with flattened endothelial cells grouped in a lobular fashion admixed with fibromyxoid stroma containing collagenous fibers, spindle cells, and mitotic figures. Preoperative work-up should include a duplex ultrasound and magnetic resonance venogram. Treatment should be with resection and specimen processing to rule-out malignant vascular tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intravenous lobular capillary hemangioma originating in the iliac veins: A case report

Pradhan

Bazan

Salem

et al. 2008

Journal of Vascular Surgery

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“…6 On rare occasions, it has been reported in organs such as liver 7 or central nervous system. 8 They have also been observed in the lumen of vessels 9 or in vascular lesions such as arteriovenous malformation 10 and capillary malformation. 11 Their pathogenesis is still poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway

2013

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Pyogenic granuloma, also called lobular capillary hemangioma, is a condition usually occurring in skin or mucosa and often related to prior local trauma or pregnancy. However, the etiopathogenesis of pyogenic granuloma is poorly understood and whether pyogenic granuloma being a reactive process or a tumor is unknown. In an attempt to clarify this issue, we performed genome-wide transcriptional profiling of lasercaptured vessels from pyogenic granuloma and from a richly vascularized tissue, placenta, as well as, from proliferative and involutive hemangiomas. Our study identified a gene signature specific to pyogenic granuloma. In the serial analysis of gene expression (SAGE) database, this signature was linked to 'white blood cells monocytes'. It also demonstrated high enrichment for gene ontology terms corresponding to 'vasculature development' and 'regulation of blood pressure'. This signature included genes of the nitric oxide pathway alongside genes related to hypoxia-induced angiogenesis and vascular injury, three conditions biologically interconnected. Finally, one of the genes specifically associated with pyogenic granuloma was FLT4, a tyrosinekinase receptor related to pathological angiogenesis. All together, these data advocate for pyogenic granuloma to be a reactive lesion resulting from tissue injury, followed by an impaired wound healing response, during which vascular growth is driven by FLT4 and the nitric oxide pathway.

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“…Le granulome pyogénique (GP) est une variante d'hémangiome capillaire, tumeur vasculaire cutanée bénigne, souvent déclenchée par des infections, des traumatismes, ou développée sur des malformations artério-veineuses [1]. Il est également décrit sous le nom d'hémangiome capillaire lobulé.…”

Section: Discussionunclassified

Une masse médiastinale postérieure…

Sauvestre

Jullié

Jougon

et al. 2015

Annales de Pathologie

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Intravascular Pyogenic Granuloma Arising in an Acquired Arteriovenous Malformation: Report of a Case and Review of the Literature

Cited by 22 publications

References 20 publications

Intravenous lobular capillary hemangioma originating in the iliac veins: A case report

Intravenous lobular capillary hemangioma originating in the iliac veins: A case report

Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway

Une masse médiastinale postérieure…

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