Intravascular papillary endothelial hyperplasia. A benign lesion mimicking angiosarcoma

Abstract

Observations were made of three cases of intravascular papillary endothelial hyperplasia (IPEH). Lesions of IPEH usually occur on the head and neck area as a subcutaneous red or blue nodule. This papillary proliferation of endothelial and stromal tissue occurs de novo in organizing venous thrombi or in preexisting hemangiomas or phlebectasias. An adequate understanding of this benign vascular disorder is important, since the lesion may be clinically and histologically mistaken for low grade angiosarcoma.

Intravascular papillary endothelial hyperplasia of the oral cavity

“…The absence of abnormal mitosis, cellular atypia, and necrosis, which are often indicative of malignancy, is a characteristic feature of IPEH (14)(15)(16). In this study, the labeling index was 4.7 to 9.2 in ki-67-positive cases.…”

Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor) as a Rare Entity on Upper Lip: A Case Report and Review

“…The papillary formation associated with thrombotic material with papillary fronds, possibly hyperchromatic endothelial cell proliferation and the endothelial cells are lined by papillary projections. [ 11 12 13 14 ] In the current report, the histopathological features of the excised specimen were endothelial cell growth with many slit-like vascular spaces. Papillary fronds with an eosinophilic hyalinized appearance and multiple capillaries were noted.…”

Intravascular Papillary Endothelial Hyperplasia of the Central Nervous System-Four Case Reports-

“…5,20,31,33) Unlike other angiomatous tumors, the proliferation of endothelial cells in IPEH is confined to the vascular lumen. The paucity of mitosis, foci of necrosis, and solid cellular areas without vessel formation may also help to distinguish this entity from neoplasms.…”