Intrauterine contraceptive devices: Failure of unilateral intrauterine device in inducing luteolysis in rabbits, rats and mice

Al-Amood, W. S.; Al-Khateeb, Eman M.; Chatterjee, R.; Chatterjee, A.

doi:10.1016/0010-7824(81)90081-0

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…20,21 The uterus of these animals consists of two long uterine horns and a short common part. The presence of a paired genital tract offers special experimental possibilities.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Hu¹,

Wang²,

Rao³

et al. 2014

IJN

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A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group ( P <0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group ( P <0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment.

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“…20,21 The uterus of these animals consists of two long uterine horns and a short common part. The presence of a paired genital tract offers special experimental possibilities.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Hu¹,

Wang²,

Rao³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…Rodents, such as rats, mice, and rabbits, have frequently been used for experimental studies on the influence of different IUDs on the FA of the endometrium [1][2][3][4][5]. The uterus of these rodents consists of two long uterine horns and a short common part.…”

Section: Introductionmentioning

confidence: 99%

Decreased fibrinolytic activity in the rat uterus after laparotomy

1985

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The influence of different intrauterine devices (IUDs) on the uterine fibrinolysis has been extensively studied in rodents with two uterine horns. In this experimental model an IUD is inserted into one horn by a surgical procedure including laparotomy and uterotomy. The effect of these two surgical steps on the fibrinolysis in the endometrium determined according to Todd's histochemical fibrin slide technique was studied in the present series comprising 26 rats. The fibrinolytic activity (FA) in the rat uterus was independent of the biopsy site in the uterine horns. However, significant depression of endometrial fibrinolysis was demonstrated 2 weeks after laparotomy, whereas no effect of a tiny incision in the uterine wall was recorded. In conclusion, a sham operation of the control horn in rodent studies on the fibrinolytic effect of IUDs according to this experimental model is not necessary.

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Intrauterine contraceptive devices: Failure of unilateral intrauterine device in inducing luteolysis in rabbits, rats and mice

Cited by 2 publications

References 19 publications

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Decreased fibrinolytic activity in the rat uterus after laparotomy

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