Intrathyroidal Plasmacytoma with Pleomorphic Multilobated Bizarre Cells: A Rare Primary Clinicopathological Presentation Mimicking Anaplastic Carcinoma of Thyroid

Pasricha, Sunil; Diwan, Himanshi; Bansal, Divya; Jajodia, Ankush; Agarwal, Mudit; Gupta, Gurudutt; Sharma, Abhimanyu; Durga, Garima; Kamboj, Meenakshi; Koyyala, Venkata Pradeep Babu; Mehta, Anurag

doi:10.1007/s12105-022-01465-2

Cited by 1 publication

(4 citation statements)

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“…CD138, kappa and lambda markers were the most employed. We found that the majority of cases underwent 95 Thyroid gland Lymphoma Pasricha et al 98 Thyroid gland Anaplastic carcinoma immunophenotyping of conventional biopsy tissue. It is worth mentioning, however, that immunocytochemical staining with a smear or cell block has been used for immunophenotyping of haematolymphoid neoplasms with promising results.…”

Section: Demographic Data and Clinical Featuresmentioning

confidence: 77%

“…The electronic searches yielded 1143 articles (PubMed: 418, Web of Science: 292, Embase: 265, and Scopus: 168) and 82 studies reporting 102 individuals were included in this systematic review 17–98 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Most cases were primary and extraosseous lesions. However, both extraosseous and intraosseous lesions result in a variety of findings, including swelling associated or not with pain, facial asymmetry, numbness, paraesthesia, and hoarseness 17–98 . Notably, the findings indicated that most cases had a diagnosis of plasmacytoma (extramedullary or solitary of bone) and the remaining ones had systemic involvement by PCM.…”

Section: Discussionmentioning

confidence: 99%

“…A recent systematic review identified concordance rates higher than 64% for the smear and 77% for the cell‐block technique regarding diagnostic capability for the evaluation of intraosseous jaw lesions, including malignant lesions 16 . Despite several published reports on the cytopathological diagnosis of PCN, either in isolated manifestations (extramedullary or solitary bone plasmacytoma) or as a consequence of PCM, 17–98 there is a lack of compiled information investigating the agreement of cytopathological and histopathological findings, along with others ancillary cytological methods such as smears and cell blocks. In fact, FNAC represents a faster, cheaper and more diversified noninvasive diagnostic approach.…”

Section: Introductionmentioning

confidence: 99%

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Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

Felix

SENA

Arruda

et al. 2022

Diagnostic Cytopathology

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Background Cytopathologic analysis is feasible and provides detailed morphological characterisation of head and neck lesions. Aims To integrate the available data published on fine‐needle aspiration cytology (FNAC) used for the diagnosis of plasma cell neoplasms (PCN) of the head and neck region. Materials and Methods Searches on PubMed, Web of Science, Embase, and Scopus were performed to compile data from case reports/case series published in English. The Joanna Briggs Institute tool was used for the critical appraisal of studies. Results A total of 82 studies comprising 102 patients were included in this review. There was a predilection for men (68.6%) (male/female ratio: 2.1:1). Individuals in their 50s (29.4%), 60s (22.5%), and 70s (22.5%) were more often affected. The thyroid gland (26.2%) was the main anatomical location, followed by scalp (15.5%), neck/cervical region (15.5%), jaws (13.6%), and major salivary glands (13.6%). For FNAC analysis, a smear was employed in 41 (40.6%) cases and a cell block was used in four (3.9%). In 56 (55.4%) reports, no cytological methods were available. Morphologically, 34 (56.7%) cases had a diagnosis of PCN with agreement between cytopathology and histopathology. The rate of wrong diagnoses when using cytology was 27.5%. Immunophenotyping was performed in 49 (48%) of the cases. The 69‐month disease‐free survival rate was 60.2%, while the 27‐month overall survival rate was 64.1%. Conclusion This study reinforces that FNAC can be an ancillary tool in the first step towards the diagnosis of PCN of the head and neck region, especially when applying a cell block for cytological analysis.

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Section: Demographic Data and Clinical Featuresmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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