Intrathecal Ropivacaine and Clonidine for Ambulatory Knee Arthroscopy

Abstract

Small-dose intrathecal clonidine (15 microg) plus 8 mg intrathecal ropivacaine produces adequate and short-lasting anesthesia for knee arthroscopy.

A Comparative Study of Intrathecal Isobaric Ropivacaine with Different Doses of Clonidine in Lower Extremity Surgery

“…Types of surgeries in all three groups were similar and were comparable amongst three groups. Results of our study were similar to De Kock et al in which they administered low dose of ropivacaine 8 mg with different doses of clonidine (15,45,75 μg) for knee arthroscopy [4] . Gonulsagiroglu et al compared same dose of clonidine 15µg & 30µg with ropivacaine 1% for lower extremity surgery and results were similar to our study [7] .…”

“…No statistically differences between patient demographics and surgery duration were found between the three groups (table1). [4], [5], [6] .…”

Effect of Clonidine and/or Fentanyl in Combination with Intrathecal Bupivacaine for Lower Limb Orthopedic Surgeries in Spinal Anaesthesia

“…10,11,12 Gautier and colleagues recommend 15 to 45 µg of clonidine as optimal for supplementing spinal anesthesia; 13 in keeping within this range, we chose 25 µg as optimal. Clonidine (15-30 µg) significantly prolongs sensory blockade and improves postoperative analgesia for gynecological operations, 14 knee arthroscopy and ambulatory inguinal herniorrhaphy. 15 The data match with our results concerning the duration of sensory blockpostoperative analgesia.…”

Intrathecal clonidine added to small-dose bupivacaine prolongs

“…Clonidine is a selective partial agonist for α-2 adrenergic receptors; the analgesic effect following its intrathecal administration is mediated spinally through the activation of postsynaptic α-2 receptors in substantia gelatinosa of the spinal cord. 12,13 Many previous studies have used intrathecal clonidine combined with opioids and local anesthetics for labour analgesia and orthopedic surgery, [14][15][16] but not for urologic surgery, particularly transurethral surgical procedures. Gautier and colleagues recommend 15 to 45 µg of clonidine as optimal for supplementing spinal anesthesia; 17 in keeping within this range, we chose 25 µg as optimal.…”