Intrastriatal implants of polymer-encapsulated PC12 cells: Effects on motor function in aged rats

Nano to micro delivery systems: targeting angiogenesis in brain tumors

“…For cell encapsulation, the alginate gel is further complexed with polycations such as Poly-L-Lysine (PLL) to form a semi-permeable membrane, which allows the delivery of different bioactive substances to the surrounding while preventing the diffusion of antibodies and other components of the immune system. Cell encapsulation has been used for broad therapeutic applications such as delivery of neuroactive agents for the treatment of age-related degeneration [69,70], Alzheimer's disease[71-74], amyotrophic lateral sclerosis [75,76], neuroprotection [77], Huntington's disease [78,79] and Parkinson's disease[80-82]. This approach has also been used to deliver inhibitors of angiogensis to glioma tumors.…”

Nano to micro delivery systems: targeting angiogenesis in brain tumors

“…For cell encapsulation, the alginate gel is further complexed with polycations such as Poly-L-Lysine (PLL) to form a semi-permeable membrane, which allows the delivery of different bioactive substances to the surrounding while preventing the diffusion of antibodies and other components of the immune system. Cell encapsulation has been used for broad therapeutic applications such as delivery of neuroactive agents for the treatment of age-related degeneration [69,70], Alzheimer's disease[71-74], amyotrophic lateral sclerosis [75,76], neuroprotection [77], Huntington's disease [78,79] and Parkinson's disease[80-82]. This approach has also been used to deliver inhibitors of angiogensis to glioma tumors.…”

Astrocyte Growth and Glial Cell Line-Derived Neurotrophic Factor Secretion in Three-Dimensional Polyethylene Terephthalate Fibrous Matrices

“…However, as the disease progresses patients experience both a decreased response to L-dopa therapy and wide fluctuations in the therapeutic response to L-dopa. In a different approach, encapsulated rat phaeochromocytoma (PC12) cells ameliorated drug-induced motor asymmetries in lesioned rats, [2][3][4][5] reduced the impairments in coordination and balance in aged rats, 6,7 and induced recovery of motor function in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primates. 8,9 However, patients grafted with human fetal DA neurons responded poorly to L-dopa because of poor survival of the grafted tissue.…”

Nano to micro delivery systems: targeting angiogenesis in brain tumors

“…For cell encapsulation, the alginate gel is further complexed with polycations such as Poly-L-Lysine (PLL) to form a semi-permeable membrane, which allows the delivery of different bioactive substances to the surrounding while preventing the diffusion of antibodies and other components of the immune system. Cell encapsulation has been used for broad therapeutic applications such as delivery of neuroactive agents for the treatment of age-related degeneration [69,70], Alzheimer's disease[71-74], amyotrophic lateral sclerosis [75,76], neuroprotection [77], Huntington's disease [78,79] and Parkinson's disease[80-82]. This approach has also been used to deliver inhibitors of angiogensis to glioma tumors.…”

Astrocyte Growth and Glial Cell Line-Derived Neurotrophic Factor Secretion in Three-Dimensional Polyethylene Terephthalate Fibrous Matrices

“…However, as the disease progresses patients experience both a decreased response to L-dopa therapy and wide fluctuations in the therapeutic response to L-dopa. In a different approach, encapsulated rat phaeochromocytoma (PC12) cells ameliorated drug-induced motor asymmetries in lesioned rats, [2][3][4][5] reduced the impairments in coordination and balance in aged rats, 6,7 and induced recovery of motor function in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primates. 8,9 However, patients grafted with human fetal DA neurons responded poorly to L-dopa because of poor survival of the grafted tissue.…”

Nano to micro delivery systems: targeting angiogenesis in brain tumors

“…For cell encapsulation, the alginate gel is further complexed with polycations such as Poly-L-Lysine (PLL) to form a semi-permeable membrane, which allows the delivery of different bioactive substances to the surrounding while preventing the diffusion of antibodies and other components of the immune system. Cell encapsulation has been used for broad therapeutic applications such as delivery of neuroactive agents for the treatment of age-related degeneration [69,70], Alzheimer's disease[71-74], amyotrophic lateral sclerosis [75,76], neuroprotection [77], Huntington's disease [78,79] and Parkinson's disease[80-82]. This approach has also been used to deliver inhibitors of angiogensis to glioma tumors.…”

Astrocyte Growth and Glial Cell Line-Derived Neurotrophic Factor Secretion in Three-Dimensional Polyethylene Terephthalate Fibrous Matrices

“…However, as the disease progresses patients experience both a decreased response to L-dopa therapy and wide fluctuations in the therapeutic response to L-dopa. In a different approach, encapsulated rat phaeochromocytoma (PC12) cells ameliorated drug-induced motor asymmetries in lesioned rats, [2][3][4][5] reduced the impairments in coordination and balance in aged rats, 6,7 and induced recovery of motor function in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primates. 8,9 However, patients grafted with human fetal DA neurons responded poorly to L-dopa because of poor survival of the grafted tissue.…”