Intraperitoneal Treatment of Kisspeptin Suppresses Appetite and Energy Expenditure and Alters Gastrointestinal Hormones in Mice

Dong, Tien S.; Vu, John P.; Oh, Suwan; Sanford, Daniel; Pisegna, Joseph R.; Germano, Patrizia M.

doi:10.1007/s10620-019-05950-7

Cited by 23 publications

(23 citation statements)

References 41 publications

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“…In our previous study, orexin, which is known to have orexigenic effects, was shown to activate intracellular calcium signaling in cultured rat sensory neurons through PKC-dependent pathway (Ozcan et al 2010). Thus, kisspeptin, which is also suggested to be an anorexigenic peptide (Dong et al 2020), and orexins show the effects on [Ca 2+ ] i signaling by different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Kisspeptin leads to calcium signaling in cultured rat dorsal root ganglion neurons

Keleştimur¹,

Bulut²,

Canpolat³

et al. 2021

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Although kisspeptin and GPR54 have been reported to be expressed in the neurons of the dorsal root ganglion (DRG) of rats, and kisspeptin has been suggested to be involved in pain modulation in rodents, there is no study on the effects and mechanisms of kisspeptin on sensory neurons. Therefore, the aim of this study was to investigate the effects and mechanism of kisspeptin on intracellular free calcium levels in cultured rat DRG neurons. Bath application of kisspeptin-10 increased intracellular free calcium levels ([Ca 2+ ] i ). In the absence of extracellular calcium, the kisspeptin induced an attenuated but still significant increase in [Ca 2+ ] i . [Ca 2+ ] i responses persisted in the presence of protein kinase C (PKC) inhibitor. Data from this study revealed that kisspeptin-10 activates [Ca 2+ ] i signaling independent of PKC in cultured rat sensory neurons suggesting that peripheral site is also involved in the pain modulating effect of kisspeptin.

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Section: Discussionmentioning

confidence: 99%

Kisspeptin leads to calcium signaling in cultured rat dorsal root ganglion neurons

Keleştimur¹,

Bulut²,

Canpolat³

et al. 2021

gpb

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“…Subcutaneous administration of kisspeptin-54 to adult male rats at a dose of 50 nmol/day for 13 days does not affect food intake (Thompson et al 2006). On the other hand, in male and female mice, intraperitoneal kisspeptin-10 (2 nmol) reduces food intake by 33% in the first 4 h following administration (Dong et al 2020). However, other groups have reported no effect on food intake following intraperitoneal administration of kisspeptin-10 (7.7 nmol) to adult male mice (Stengel et al 2011).…”

Section: Kisspeptin and Appetite/food Intake Regulationmentioning

confidence: 95%

“…Taken together, these knockout studies suggest kisspeptin may reduce BAT-dependent energy expenditure but enhances total energy expenditure. However, peripheral administration of a single dose of kisspeptin-10 reduces energy expenditure in male and female mice (Dong et al 2020). Kisspeptin-10 has a short half-life (i.e.…”

Section: Kisspeptin and Energy Expenditurementioning

confidence: 99%

“…Apart from two studies in male mice in which acute kisspeptin administration reduced insulin secretion (Chen et al 2014;Song et al 2014), all other in vivo studies of acute peripheral kisspeptin administration to male and female mice (Dong et al 2020), male rats (Bowe et al 2009) and male monkeys (Wahab et al 2011) have reported increased GSIS in response to kisspeptin administration. The effects of kisspeptin on insulin secretion appear to be peripherally-mediated as i.c.v.…”

Section: Kisspeptin and Glucose Homeostasismentioning

confidence: 99%

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Emerging roles for kisspeptin in metabolism

Izzi‐Engbeaya

Dhillo

2021

The Journal of Physiology

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Kisspeptin, a neuropeptide hormone, has been firmly established as a key regulator of the hypothalamic-pituitary-gonadal axis and mammalian reproductive behaviour. In recent years, a growing body of evidence has emerged suggesting a role for kisspeptin in regulating metabolic processes. This data suggest that kisspeptin exerts its metabolic effects indirectly via Chioma Izzi-Engbeaya (MBBS PhD MRCP) is an Imperial-BRC Research Fellow at Imperial College London and a Consultant Endocrinologist at Imperial College Healthcare NHS Trust. Her research focuses on the hormonal control of metabolism and reproduction. Her work demonstrated for the first time in humans that kisspeptin enhances insulin secretion. Additionally, she is pioneering the use of novel techniques such as thermal imaging to study brown adipose tissue activation and the use of aptamer-based hormone measurement. Waljit Dhillo (MBBS PhD FRCP) is a Professor of Endocrinology and Metabolism at Imperial College London and a Consultant Endocrinologist at Imperial College Healthcare NHS Trust. His research has focused on understanding the neuroendocrine mechanisms which are important in the regulation of food intake. Furthermore, his recent pioneering translational research has identified kisspeptin as a novel therapeutic target for patients with infertility and NK3 receptor antagonists as a new treatment for post-menopausal flushing.

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“…Dong et al showed that the intraperitoneal dose of KP10 reduces food intake in the first 4 h after injection. An increase in the level of leptin, resistin and insulin was also observed [ 94 ]. A similar effect in reducing food intake was obtained by Stengel et al, after administering kisspeptin centrally in mice [ 95 ].…”

Section: Kisspeptinmentioning

confidence: 99%

The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions

Kołodziejski

Pruszyńska‐Oszmałek

Wojciechowicz

et al. 2021

Genes

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Peptide hormones play a prominent role in controlling energy homeostasis and metabolism. They have been implicated in controlling appetite, the function of the gastrointestinal and cardiovascular systems, energy expenditure, and reproduction. Furthermore, there is growing evidence indicating that peptide hormones and their receptors contribute to energy homeostasis regulation by interacting with white and brown adipose tissue. In this article, we review and discuss the literature addressing the role of selected peptide hormones discovered in the 21st century (adropin, apelin, elabela, irisin, kisspeptin, MOTS-c, phoenixin, spexin, and neuropeptides B and W) in controlling white and brown adipogenesis. Furthermore, we elaborate how these hormones control adipose tissue functions in vitro and in vivo.

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Intraperitoneal Treatment of Kisspeptin Suppresses Appetite and Energy Expenditure and Alters Gastrointestinal Hormones in Mice

Cited by 23 publications

References 41 publications

Kisspeptin leads to calcium signaling in cultured rat dorsal root ganglion neurons

Kisspeptin leads to calcium signaling in cultured rat dorsal root ganglion neurons

Emerging roles for kisspeptin in metabolism

The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions

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