Intrapancreatic Adipocyte Deposition in a Mouse Model of the Metabolic Syndrome

Ülgen, F; Scherbaum, Werner A.; Partke, HJ; Bornstein, Stefan R.; Schinner, Sven

doi:10.1055/s-2008-1062722

Cited by 3 publications

(1 citation statement)

References 10 publications

(14 reference statements)

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“…Consistently, a systemic analysis of an obese, insulin resistant and hyperinsulinemic mouse model New Zealand-obese mouse revealed a massive increase of intra-pancreatic adipocyte deposition compared with wild-type animals. In addition, histological studies showed proximity of adipocytes and islets in these animals, suggesting paracrine effects on adipocytes on b-cells (38).…”

Section: How Can Adipocyte-derived Wnts Reach Endocrine Cells?mentioning

confidence: 99%

Pathophysiological aspects of Wnt-signaling in endocrine disease

Schinner

Willenberg

Schott

et al. 2009

European Journal of Endocrinology

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Wnt-signaling has recently been identified as a regulator of a number of endocrine functions in health and disease in addition to its original attribution to developmental biology. Wnts are extracellular ligands on frizzled receptors and on lipoprotein receptor-related protein co-receptors. Ligand binding leads eventually to the activation of intracellular signaling cascades; based on the involvement of the transcriptional co-activator b-catenin it can be distinguished between canonical (i.e. b-catenin) and non-canonical Wnt-signaling. Recent studies revealed that canonical Wnt-signaling regulates the function of endocrine organs and contributes to a number of endocrine disorders. In this review, we would like to focus on a) recent mechanistic data on Wnts in pancreatic b-cell function; b) human genetic studies on Wnt signaling in type 2 diabetes mellitus; c) crosstalk between adipocytes and endocrine cells through Wnt-signaling molecules (with a focus on the role of Wnt-signaling in adrenocortical cells).European Journal of Endocrinology 160 731-737

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Section: How Can Adipocyte-derived Wnts Reach Endocrine Cells?mentioning

confidence: 99%