Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial

Veronesi, Umberto; Orecchia, Roberto; Maisonneuve, Patrick; Viale, Giuseppe; Rotmensz, Nicole; Sangalli, Claudia; Luini, Alberto; Veronesi, Paolo; Galimberti, Viviana; Zurrida, Stefano; Leonardi, Maria Cristina; Lazzari, Roberta; Cattani, Federica; Gentilini, Oreste; Intra, Mattia; Caldarella, Pietro; Ballardini, B.

doi:10.1016/s1470-2045(13)70497-2

Cited by 676 publications

(562 citation statements)

References 30 publications

Supporting

Mentioning

494

Contrasting

Unclassified

Order By: Relevance

“…Two large phase 3 trials, the Intraoperative radiotherapy with electrons (ELIOT) trial and the TARGIT trial, compared WBI with IORT PBI using either electron beam (ELIOT) 21 or low-energy x-rays (Intrabeam device, TARGIT). 22 Both trials reported increased risk of IBTR after IORT.…”

Section: Clinical Trialsmentioning

confidence: 99%

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Correa

Harris

Leonardi

et al. 2017

Practical Radiation Oncology

Self Cite

500

313

View full text Add to dashboard Cite

Section: Clinical Trialsmentioning

confidence: 99%

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Correa

Harris

Leonardi

et al. 2017

Practical Radiation Oncology

Self Cite

500

313

View full text Add to dashboard Cite

“…Полученные данные являются еще одним клиническим доказательством безопасности использования внутритканевой мультикатетерной бра-хитерапии для проведения APBI у больных РМЖ низ-кого риска после органосохраняющего лечения [25].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Results of Early-Stage Breast Cancer Patients’ Treatment Using Accelerated Partial Breast Irradiation Technique After Breast-Conserving Surgery. Experience of N.N. Blokhin National Medical Research Center of Oncology

Трофимова¹,

Волкова²,

Nazarenko³

et al. 2017

Tumors of female reproductive system

View full text Add to dashboard Cite

show abstract

“…The use of IORT should decrease the exposure of other tissues like skin, soft tissue, heart, and lung to the damaging effects of radiation. When 21 Gy IORT is compared to 50 Gy fractioned external beam radiation therapy (EBRT) there is a 4.8% absolute increased risk of recurrence but no change in mortality [6]. In those patients at high risk for recurrence, boost IORT with a lower dose can precede EBRT.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Radiation Therapy for Breast Cancer Not Associated with Pulmonary Complications

Kalos¹,

Lund²,

Visco³

et al. 2014

J Nucl Med Radiat Ther

View full text Add to dashboard Cite

Radiation pneumonitis and radiation-induced cryptogenic organizing pneumonia are common complications after external beam radiation therapy following breast conserving surgery for patients with early stage breast cancer. Intraoperative radiation therapy (IORT) is designed to decrease radiation exposure to the lung, skin, soft tissue, and contralateral breast. A single-center, retrospective cohort of all patients receiving IORT between 2009 and 2013 was analyzed, and 122 cases of IORT were found. There were no instances of pulmonary complication in patients receiving IORT without whole breast irradiation. The only instance of radiation pneumonitis identified was in a patient who received subsequent external beam radiation after boost IORT. As there are no previous systemic evaluations of pulmonary complications of IORT, this study supports its reported safety.

show abstract

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial

Cited by 676 publications

References 30 publications

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Results of Early-Stage Breast Cancer Patients’ Treatment Using Accelerated Partial Breast Irradiation Technique After Breast-Conserving Surgery. Experience of N.N. Blokhin National Medical Research Center of Oncology

Intraoperative Radiation Therapy for Breast Cancer Not Associated with Pulmonary Complications

Contact Info

Product

Resources

About