Intraoperative radiation therapy with electrons (ELIOT) in early-stage breast cancer

Orecchia, Roberto; Ciocca, Mario; Lazzari, Roberta; Garibaldi, Cristina; Leonardi, Maria Cristina; Luini, Alberto; Intra, Mattia; Gatti, Giovanna; Veronesi, Paolo; Petit, Jm.; Veronesi, Umberto

doi:10.1016/s0960-9776(03)00156-5

Cited by 124 publications

(66 citation statements)

References 22 publications

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“…There are several other trials of partial breast irradiation that use various techniques, including the ELIOT, 47 NSABP-B39, GEC ESTRO, and Hungarian trials. 48 The ELIOT trial 47 is the only other trial that uses single fraction intraoperative radiotherapy and a mobile linear accelerator that generates electrons at various energy levels.…”

Section: Discussionmentioning

confidence: 99%

“…48 The ELIOT trial 47 is the only other trial that uses single fraction intraoperative radiotherapy and a mobile linear accelerator that generates electrons at various energy levels. While the radiotherapy with targeted intraoperative treatment is given from within the breast with minimum additional dissection of the breast, the ELIOT technique 47 requires the breast tissue to be dissected off the skin and the chest wall and brought together for irradiation from outside the breast. The other trials use well-established techniques such as radioactive interstitial implants, intensity modulated and three-dimensional conformal radiotherapy, and interstitial balloon devices.…”

Section: Discussionmentioning

confidence: 99%

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Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

et al. 2010

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SummaryBackground After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

et al. 2010

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“…Due to its low energy deposition range, electron beams are widely used in the treatment of superficial tumors but they are also suitable to intra-operative radiotherapy (IORT) [1,2].…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo simulation as an auxiliary tool for electron beam quality specification for intra-operative radiotherapy

Neto¹,

Haddad²,

Pelosi³

et al. 2005

Braz. J. Phys.

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Intra-operative radiotherapy (IORT) using electron beams has demonstrated to be a good alternative as part of the breast-conserving surgery. Besides, as the computer processing capacity has been increasing along the years, it has become a potential auxiliary tool in radiotherapy treatment planning. In this work these streams are merged together: simulations were performed by different Monte Carlo radiation transport codes (EGS4 and MCNP in its releases 4C and 5) in an attempt to not only examine the efficacy of Al and Pb discs used in IORT procedures to protect critical regions but also to compare the performance of the forementioned codes.

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“…6,7 In the pilot study (escalation dose) on 101 patients, after a mean follow- Umberto Veronesi is Scientific Director of the European Institute of Oncology in Milan, Italy. Professor Veronesi was the first to demonstrate that conservative breast surgery plus radiotherapy, which leaves the breast intact, can replace mutilating mastectomy and yet obtain the same cure rates.…”

mentioning

confidence: 99%

“…6,7 In the pilot study (escalation dose) on 101 patients, after a mean follow- against the causes and consequences of cancer…”

mentioning

confidence: 99%

Breast Cancer and Intra-operative Radiotherapy with Electrons at the European Institute of Oncology

Veronesi¹,

Zurrida²

2007

European Oncology &Amp; Haematology

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The current standard treatment for early breast cancer includes conservative surgery followed by radiotherapy to the whole breast. 1 Longterm follow-up of patients included in the Milan Three Trial (Quart versus Tart) showed that most local relapses occur in the area of the scar tissue, 2 suggesting that total irradiation of the breast may not always be necessary.We started our experience in intra-operative radiotherapy for breast cancer in June 1999 with a dose-finding study to test the feasibility of this new approach during breast-conserving surgery. 3 Electron intra-operative therapy (ELIOT) exploits new technologies that make it possible to deliver radiation to a more circumscribed area of the breast. The technique also markedly reduces the time required for a radiotherapy course, improving the quality of life of the patients. From June 1999 to October 2000, we experimented with different dose levels and verified the tolerance of 21Gy prescribed at 90% isodose as a full dose of intra-operative radiotherapy for small-size breast tumours (maximum tumour diameter 2.5cm). 4,5 The different dose levels are reported in Table 1. Dose levels of 10 and 15Gy were followed by a reduced course of external fractionated radiotherapy.We obtained excellent results in terms of acute and intermediate tolerance of treatment and we adopted the dose of 21Gy prescribed at 90% isodose as the full dose approach for the randomised trial. 6,7 In the pilot study (escalation dose) on 101 patients, after a mean follow- Umberto Veronesi is Scientific Director of the European Institute of Oncology in Milan, Italy. Professor Veronesi was the first to demonstrate that conservative breast surgery plus radiotherapy, which leaves the breast intact, can replace mutilating mastectomy and yet obtain the same cure rates. More recently, he has developed new researches with the sentinel node biopsy procedure to avoid axillary dissection when the lymph nodes are not involved. Professor Veronesi was awarded eight honoris causa in medicine and has published over 700 papers and many textbooks. He gained his medical degree

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Intraoperative radiation therapy with electrons (ELIOT) in early-stage breast cancer

Cited by 124 publications

References 22 publications

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Monte Carlo simulation as an auxiliary tool for electron beam quality specification for intra-operative radiotherapy

Breast Cancer and Intra-operative Radiotherapy with Electrons at the European Institute of Oncology

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