Intraoperative Injection of Radiocolloid for Sentinel Node Biopsy in Breast Cancer

Vu, Huan; O’Connor, P; Shoemaker, Rebecca; Wan, Wen; Fratkin, Melvin J.; Bear, Harry D.

doi:10.2967/jnmt.113.129460

Cited by 9 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 739 SNBs analyzed, 647 had PRCI and 92 had IRCI. The overall SNIDR were similar for the two groups: 93.5% for PRCI and 94.6% for IRCI [8]. The overall rates of positive sentinel nodes were comparable for the two groups: 25.6% for the PRCI group and 26.4% for the IRCI group.…”

Section: Discussionmentioning

confidence: 80%

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Shoemaker

O’Connor

et al. 2015

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 80%

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Shoemaker

O’Connor

et al. 2015

Journal of Surgical Research

View full text Add to dashboard Cite

“…>90%) is a prerequisite for safe diagnosis and therapy of diseases in oncology set-up. 14 The colloidal particles that exceed in size from 0.22 µm may block the blood capillaries and consequently lead to nonspecific accumulation and radiotoxicity, 15 while the free 99m TcO 4 −1 lead to nonspecific distribution throughout the body making high background activity and made confusion during locating the area of interest. 16 The least radioactive impurities greatly contribute in scintigraphy imaging and therapeutic outcome of newly developed radiopharmaceuticals.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Internalization and Externalization Integrity Study of Newly Synthesized ^99mTc-Thymoquinone Radiopharmaceutical as Cancer Theranostic Agent

et al. 2020

View full text Add to dashboard Cite

Thymoquinone (TQ) is a bioactive phytochemical isolated from Nigella sativa and has been investigated for biochemical and biological activities in both in vitro and in vivo models. It is best known for its anticancer activities. Thymoquinone accomplishes anticancer activities through targeting multiple cancer markers including PPAR-γ, PTEN, P53, P73, STAT3, and generation of reactive oxygen species at the cancer cell surface. The radiolabeling of TQ with γ- and β-emitter radionuclide could be used as cancer diagnostic or therapeutic radiopharmaceutical, respectively. In this study, we are reporting the radiolabeling of TQ with technetium-99m (99mTc), stability in saline and blood serum, internalization and externalization of 99mTc-TQ using rhabdomyosarcoma cancer cells line. The quality control study revealed more than 95% labeling yield and stable in blood serum up to 4 hours. In vitro internalization rate was recorded 27.08% ± 0.95% at 1 hour post 2 hours internalization period and comparatively slow externalization. The results of this study are quite encourging and could be investigated for further key preclinical parameters to enter phase I clinical trials.

show abstract

“…A sentinel lymph node biopsy (SNB) has been established as the standard method for staging clinically node-negative breast cancer [1,2], and an SNB technique using superparamagnetic iron oxide (SPIO) nanoparticles and a handheld magnetometer has been reported [3]. While the radioisotope (RI) and dyecombined method has been thought to be the standard, an SNB using SPIO has been adopted because the RI method has disadvantages of radiation exposure [4], regulations regarding radioisotope management [5], and painful tracer injection [6,7].…”

Section: Introductionmentioning

confidence: 99%

Moving a neodymium magnet promotes the migration of a magnetic tracer and increases the monitoring counts on the skin surface of sentinel lymph nodes in breast cancer

et al. 2020

View full text Add to dashboard Cite

Background: We suspected that moving a small neodymium magnet would promote migration of the magnetic tracer to the sentinel lymph node (SLN). Higher monitoring counts on the skin surface before making an incision help us detect SLNs easily and successfully. The present study evaluated the enhancement of the monitoring count on the skin surface in SLN detection based on the magnet movement in a sentinel lymph node biopsy (SNB) using superparamagnetic iron oxide (SPIO) nanoparticles. Methods: After induction of general anesthesia, superparamagnetic iron oxide nanoparticles were injected subdermally into the subareolar area or peritumorally. The neodymium magnet was moved over the skin from the injection site to the axilla to promote migration of the magnetic tracer without massage. A total of 62 patients were enrolled from February 2018 to November 2018: 13 cases were subjected to magnet movement 20 times (Group A), 8 were subjected to 1-min magnet movement (Group B), 26 were given a short (about 5 min) interval from injection to 1-min magnet movement (Group C), and 15 were given a long (about 25 min) interval before 1min magnet movement using the magnetometer's head (Group D). In all cases, an SNB was conducted using both the radioisotope (RI) and SPIO methods. The monitoring counts on the skin surface were measured by a handheld magnetometer and compared among the four groups. Changes in the monitoring count by the interval and magnet movement were evaluated.

show abstract

Intraoperative Injection of Radiocolloid for Sentinel Node Biopsy in Breast Cancer

Cited by 9 publications

References 17 publications

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Dose-Dependent Internalization and Externalization Integrity Study of Newly Synthesized ^99mTc-Thymoquinone Radiopharmaceutical as Cancer Theranostic Agent

Moving a neodymium magnet promotes the migration of a magnetic tracer and increases the monitoring counts on the skin surface of sentinel lymph nodes in breast cancer

Contact Info

Product

Resources

About

Intraoperative Injection of Radiocolloid for Sentinel Node Biopsy in Breast Cancer

Cited by 9 publications

References 17 publications

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Intraoperative radiocolloid injection for sentinel node biopsy postneoadjuvant chemotherapy

Dose-Dependent Internalization and Externalization Integrity Study of Newly Synthesized 99mTc-Thymoquinone Radiopharmaceutical as Cancer Theranostic Agent

Moving a neodymium magnet promotes the migration of a magnetic tracer and increases the monitoring counts on the skin surface of sentinel lymph nodes in breast cancer

Contact Info

Product

Resources

About

Dose-Dependent Internalization and Externalization Integrity Study of Newly Synthesized ^99mTc-Thymoquinone Radiopharmaceutical as Cancer Theranostic Agent