Intraoperative experiments show relevance of inter-antagonistic mechanical interaction for spastic muscle's contribution to joint movement disorder

Ateş, Filiz; Temelli, Yener; Yücesoy, Can A.

doi:10.1016/j.clinbiomech.2014.06.010

Cited by 31 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This agrees with our present findings for CP patients. Note that, earlier data published showing KA-F GRA curves in CP patients (Ates et al, 2014) and healthy adults undergoing anterior cruciate ligament reconstruction surgery (Yucesoy et al, 2010a) also show a qualitative similarity and e.g., comparable %F GRApeak|120°( %59.4 ± 31.6 vs. %56.4 ± 31.1, respectively). GRA muscle in healthy subjects has long fibers (Makihara et al, 2006) and large excursion (Ward et al, 2009).…”

Section: Discussionsupporting

confidence: 51%

“…This is ascribed to further loading of the epimuscular connections by the active muscles, causing them to operate at higher stiffness with a bigger potential to impose an effect on the muscle. Supporting this, recent intraoperative data show that spastic GRA stimulated simultaneously with its antagonist vastus medialis has a narrow operational knee joint range of force exertion and high capacity of force production in flexed knee positions (Ates et al, 2014).…”

Section: Discussionmentioning

confidence: 88%

“…A KA-F ST curve other than that was considered as (I) abnormal if the KA FSTpeak was between KA = 120°and KA = 90°, or otherwise, if %F STpeak|120°P 80% or %F STpeak|90°P 80%; (II) normal if KA FSTpeak was beyond KA = 90°with %F STpeak|90°< 80% and F ST|120°< F ST|90°. These criteria allow testing the hypothesis quantitatively based on the thresholds used earlier (Ates et al, 2014). They characterize expected narrow joint range of muscle force exertion and high force production capacity of spastic muscle in flexed joint positions that could explain its role in the pathological knee joint condition.…”

Section: Processing Of Datamentioning

confidence: 99%

See 2 more Smart Citations

The mechanics of activated semitendinosus are not representative of the pathological knee joint condition of children with cerebral palsy

Ateş

Temelli

Yücesoy

2016

Journal of Electromyography and Kinesiology

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 88%

Section: Processing Of Datamentioning

confidence: 99%

See 1 more Smart Citation

The mechanics of activated semitendinosus are not representative of the pathological knee joint condition of children with cerebral palsy

Ateş

Temelli

Yücesoy

2016

Journal of Electromyography and Kinesiology

Self Cite

View full text Add to dashboard Cite

“…Although the latter test was not conducted presently, the findings (i) in contrast, do not show a diminished EMFT in the long term, but judging from the elevated distally directed myofascial loads, and (ii) indicate that intermuscular connective tissue linkages between the TA and the EDL should be stiffer. This issue is relevant because for patients with CP, recent intraoperative experiments show that inter-synergistic EMFT ( Ates et al, 2018b ; Kaya et al, 2018 , 2019 , 2020 ) and also the inter-antagonistic EMFT ( Ates et al, 2014 , 2018b ; Kaya et al, 2019 , 2020 ) cause a significant increase in the force of spastic gracilis and semitendinosus muscles (above 30%, up to 70%). This suggests that the spastic hamstrings capacity to affect the pathological condition in the joint is changed by EMFT.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects With Potential Clinical Importance of Botulinum Toxin Type-A on Mechanics of Muscles Exposed

Kaya

Yılmaz

Akdeniz-Doğan

et al. 2020

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Botulinum toxin type-A (BTX-A) is widely used for spasticity management and mechanically aims at reducing passive resistance at the joint and widening joint range of movement. However, recent experiments on acute BTX-A effects showed that the injected rat tibialis anterior (TA) muscle's passive forces increased, and the length range of active force exertion (l range) did not change. Additionally, BTX-A was shown to spread into non-injected muscles in the compartment and affect their mechanics. Whether those effects persist in the long term is highly important, but unknown. The aim was to test the following hypotheses with experiments conducted in the anterior crural compartment of the rat: In the long term, BTX-A (1) maintains l range , (2) increases passive forces of the injected TA muscle, and (3) spreads into non-injected extensor digitorum longus (EDL) and the extensor hallucis longus (EHL) muscles, also affecting their active and passive forces. Male Wistar rats were divided into two groups: BTX-A and Control (0.1 units of BTX-A or only saline was injected into the TA). Isometric forces of the muscles were measured simultaneously 1-month post-injection. The targeted TA was lengthened, whereas the non-targeted EDL and EHL were kept at constant length. Hydroxyproline analysis was done to quantify changes in the collagen content of studied muscles. Two-way ANOVA test (for muscle forces, factors: TA length and animal group) and unpaired t or Mann-Whitney U test (for l range and collagen content, where appropriate) were used for statistical analyses (P < 0.05). BTX-A caused significant effects. TA: active forces decreased (maximally by 75.2% at short and minimally by 48.3%, at long muscle lengths), l range decreased (by 22.9%), passive forces increased (by 12.3%), and collagen content increased (approximately threefold). EDL and EHL: active forces decreased (up to 66.8%), passive force increased (minimally by 62.5%), and collagen content increased (approximately twofold). Therefore, hypothesis 1 was rejected and 2 and 3 were confirmed indicating that previously reported acute BTX-A effects persist and advance in the long term. A narrower l range and an elevated passive resistance of the targeted muscle are unintended mechanical effects, whereas spread of BTX-A into other compartmental muscles indicates the presence of uncontrolled mechanical effects.

show abstract

“…This indicates that IMP reflects local intramuscular mechanical changes that occur before measured joint torque production. Recent studies showed that forces measured directly from the tendon do not necessarily represent the muscular condition for spastic muscles (Ates et al, 2013b, 2014, 2016; Yucesoy et al, 2017). Therefore, to better understand the musculoskeletal changes due to diseases, it is essential to obtain local properties of diseased muscles.…”

Section: Discussionmentioning

confidence: 99%

Intramuscular Pressure of Human Tibialis Anterior Muscle Reflects in vivo Muscular Activity

et al. 2019

Self Cite

View full text Add to dashboard Cite

Intramuscular pressure (IMP) is the fluid hydrostatic pressure generated within a muscle and reflects the mechanical forces produced by a muscle. By providing accurate quantification of interstitial fluid pressure, the measurement of IMP may be useful to detect changes in skeletal muscle function not identified with established techniques. However, the relationship between IMP and muscle activity has never been studied in vivo in healthy human muscles. To determine if IMP is able to evaluate electromechanical performance of muscles in vivo , we tested the following hypotheses on the human tibialis anterior (TA) muscle: (i) IMP increases in proportion to muscle activity as measured by electrical [Compound Muscle Action Potential (CMAP)] and mechanical (ankle torque) responses to activation by nerve stimulation and (ii) the onset delay of IMP (IMPD) is shorter than the ankle torque electromechanical delay (EMD). Twelve healthy adults [six females; mean (SD) = 28.1 (5.0) years old] were recruited. Ankle torque, TA IMP, and CMAP responses were collected during maximal stimulation of the fibular nerve at different intensity levels of electrical stimulation, and at different frequencies of supramaximal stimulation, i.e., at 2, 5, 10, and 20 Hz. The IMP response at different stimulation intensities was correlated with the CMAP amplitude ( r 2 = 0.94). The area of the IMP response at different stimulation intensities was also significantly correlated with the area of the CMAP ( r 2 = 0.93). Increasing stimulation intensity resulted in an increase of the IMP response ( P < 0.001). Increasing stimulation frequency caused torque ( P < 0.001) as well as the IMP ( P < 0.001) to increase. The ankle torque EMD [median (interquartile range) = 41.8 (14.4) ms] was later than the IMPD [33.0 (23.6) ms]. These findings support the hypotheses and suggest that IMP captures active mechanical properties of muscle in vivo and can be used to detect muscular changes due to drugs, diseases, or aging.

show abstract

Intraoperative experiments show relevance of inter-antagonistic mechanical interaction for spastic muscle's contribution to joint movement disorder

Cited by 31 publications

References 51 publications

The mechanics of activated semitendinosus are not representative of the pathological knee joint condition of children with cerebral palsy

The mechanics of activated semitendinosus are not representative of the pathological knee joint condition of children with cerebral palsy

Long-Term Effects With Potential Clinical Importance of Botulinum Toxin Type-A on Mechanics of Muscles Exposed

Intramuscular Pressure of Human Tibialis Anterior Muscle Reflects in vivo Muscular Activity

Contact Info

Product

Resources

About