1994
DOI: 10.1118/1.597240
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Abstract: An intraoperative beta probe was designed, built, and tested for detection of radio-labeled malignant tissues that has the advantage of being selectively sensitive to beta while insensitive to gamma radiation. Since beta radiation (electrons or positrons) has a short range in tissue, this probe is ideal for detecting tracers in tumors at the surface of the surgical field. This probe contains a plastic scintillation detector sensitive to beta rays and to a lesser degree some background gamma rays. A second dete… Show more

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Cited by 110 publications
(76 citation statements)
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“…Because of the limited spatial resolution and partialvolume effects of small-animal PET, additional experiments with b-microprobes were also executed. b-microprobes-radiosensitive probes implanted stereotactically in anesthetized animals-record real-time kinetics of positron emitters within a few millimeters around the tip of the probe (10). To validate our b-microprobe setup with 11 C-ABP688, we implanted b-microprobes in the caudate putamen and cerebellum of untreated animals (n 5 6); we also performed a blocking study with unlabeled ABP688 (n 5 6).…”
mentioning
confidence: 99%
“…Because of the limited spatial resolution and partialvolume effects of small-animal PET, additional experiments with b-microprobes were also executed. b-microprobes-radiosensitive probes implanted stereotactically in anesthetized animals-record real-time kinetics of positron emitters within a few millimeters around the tip of the probe (10). To validate our b-microprobe setup with 11 C-ABP688, we implanted b-microprobes in the caudate putamen and cerebellum of untreated animals (n 5 6); we also performed a blocking study with unlabeled ABP688 (n 5 6).…”
mentioning
confidence: 99%
“…They are capable of scanning arbitrary surfaces with a spatial accuracy only limited by the sensor size. Beta-probes are a specially interesting variant, since positrons (beta-plus-particles) penetrate tissue only up to 2 [mm] [3,5]. This justifies the assumption that the activity measured is located at the surface next to the distal end of the probe and thus enables good spatial accuracy in detection.…”
Section: Requirements and Design Considerationsmentioning
confidence: 99%
“…Recently beta-probes have been introduced to improve the detection of remanent malignant tumor cells by means of nuclear labeling [3,4]. A cancer marker like FDG 1 , is injected into the patient before surgery.…”
Section: Introductionmentioning
confidence: 99%
“…Scintillators can produce between 1,000 and more than 100,000 photons per MeV, depending on the material used (11). Scintillators have been incorporated into handheld radioactive probes and cameras for radio-guided surgical applications (12)(13)(14)(15)(16).…”
mentioning
confidence: 99%