Intraocular Lens Calcification After Keratoplasty

Abstract

IOL calcification associated with keratoplasty in our series does not seem to be a problem related to a specific IOL model or polymer. The process of calcification may be mediated by inflammation, which also may be related to multiple injections of air into the anterior chamber.

Microscopic analysis of an opacified OFT CRYL® hydrophilic acrylic intraocular lens

“…This was our first case of opacification. Thus, this IOL should not be discredited based on the current report, which supports the hypothesis that intracameral gas can act as a trigger of hydrophilic lens calcification (2)(3)(4)(5)(6)(7)(8)(9) . Together with previous articles (2)(3)(4)(5)(6)(7)(8)(9) , the present report suggests that hydrophilic IOLs should be avoided in eyes that require procedures associated with intracameral presence of air or gas.…”

“…Similarly to the pattern seen in the Oft Cryl® IOL, calcification within the pupillary and anterior capsulorrhexis margins has been described in eyes in which gas or air 1) was injected intracamerally to treat Descemet's membrane detachment, to aid in graft adherence in endothelial transplants; 2) was injected to treat hypotony following trabeculoplasty; or 3) went into the anterior chamber after injection in the vitreous cavity to treat retinal detachment and ocular hypotony (2)(3)(4)(5)(6)(7)(8) . In these lenses, calcium granules were also found on the surface and subsurface of the IOLs.…”

“…Previous papers have described cases of IOL opacification in hydrophilic acrylic IOLs from different manufacturers (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) . However, to the best of our knowledge, this is the first peer-reviewed report on Oft Cryl® IOL opacification.…”

“…Recently, opacification associated with the presence of gas or air in the anterior chamber has been reported (2)(3)(4)(5)(6)(7)(8)(9) . Since 2005, the single-piece hydrophilic acrylic Oft Cryl® IOL (Oft Vision, São Paulo, Brazil) has been largely used in Brazil; however, no case of lens opacification has been reported in the peer-reviewed scientific literature.…”

Intraocular lens calcification following endothelial keratoplasty: a message for all cataract surgeons

“…This series supports previous observations that such opacification appears to be almost unique to hydrophilic acrylic IOL's, and furthermore, having air or gas in the anterior chamber appears to be a risk factor. 2,3 However, it is certainly possible for this complication to occur without rebubbling. Although all four cases had rebubbling in this series, 1 in our recently published UK series only two of the five cases had rebubbling.…”