Intranasal trigeminal chemosensitivity in patients with postviral and post-traumatic olfactory dysfunction

Ren, Yuanyuan; Yang, Ling; Guo, Yichen; Miao, Xutao; Li, Kunyan; Wei, Yongxiang

doi:10.3109/00016489.2012.663933

Cited by 22 publications

(17 citation statements)

References 23 publications

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“…A growing body of evidence also indicates that olfactory performance differences are not significant between older females and males (26)(27)(28) . This is consistent with the results of some other studies examining difference across life stages, that is, from prepubertal to elderly participants or from young to elderly adults, that found no significant gender differences (29)(30)(31)(32) .…”

Section: Introductionsupporting

confidence: 92%

Effect of gender on odor identification at different life stages: a meta-analysis

Wang¹,

Zhang²,

Xia³

et al. 2019

Rhin

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Background: Although conflicting findings abound, gender-related differences in olfactory identification have received continuous attention. To our best knowledge, no systematic and quantitative research has examined gender differences in olfaction identification at various stages of life. The present study aimed to find out if there is gender difference in human olfaction identification in different life stages. Methodology: Studies cited in the PubMed database were searched from its inception to August 2017 using the terms "olfact*" or "smell" and "gender" or "sex". The effect size of each comparison was calculated. 24 studies were included in this meta-analysis. Results: In this meta-analysis, we used Cohen's d to determine the effects sizes for the comparisons between women versus men among different groups. Its value was 0.18 (95% CI:-0.13 to 0.49) in Group A (age<18years), 0.62 (95% CI: 0.43 to 0.81) in Group B (age 18-50years), and 0.33 (95% CI:-0.01 to 0.66) in Group C. The effect was considered relatively small in Group A (age<18years) and Group C (age>50years), and a medium effect in Group B (age18-50 years). Moreover, a significant difference was only present in Group B (age18-50 years). Summarizing, the gender effect was only present in the group aged 18-50 years, in which women outperformed men significantly in odor identification. Conclusions: This meta-analytic review indicated that the gender differences only exist in young adults (age18-50 years), while absent in juveniles (age<18years) or an aged cohort (age >50years). Females outperformed males in the young adults.

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Section: Introductionsupporting

confidence: 92%

Effect of gender on odor identification at different life stages: a meta-analysis

Wang¹,

Zhang²,

Xia³

et al. 2019

Rhin

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“…Our results are in accordance with a recently published study by Parma et al [16], where the authors divided COVID-19 patients into 3 phenotypic clusters, with one of them having a loss of smell, taste, and chemesthesis. Although this phenomenon has been described in previous studies, it was rarely reported by the patients [17, 18]. The mechanisms are not clear and may be both peripheral and central.…”

Section: Discussionmentioning

confidence: 78%

Short-Term Follow-Up of Self-Isolated COVID-19 Patients with Smell and Taste Dysfunction in Greece: Two Phenotypes of Recovery

Konstantinidis

Delides

Tsakiropoulou

et al. 2020

ORL

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Introduction: The course of anosmia and ageusia in COVID-19 patients is not yet clearly known. We present short-term follow-up data concerning mild to moderate disease in home-quarantined COVID-19 patients in Greece. Methods: We provided a symptom questionnaire and instructions for a self-administered home smell-and-taste test to 79 positive COVID-19 patients from 2 tertiary hospitals in Greece. The patients recorded their subjective symptoms before and during infection as well as 4 weeks after the diagnosis. The patients also underwent the home test during infection and 4 weeks later. Results: Twenty-nine patients (36.7%) reported a loss of smell, and 21 (27.8%) reported a loss of taste, with equal prevalences between genders. We observed 2 types of recovery, i.e., a rapid, almost complete recovery, and a second slower and partial recovery. The type of recovery was not age related. A rapid recovery was observed in two thirds of the patients, with their olfactory ratings presenting a trend towards significance in correlation with nasal obstruction. A slow recovery in olfaction was correlated with low intensity ratings in odors with a trigeminal compound. The loss of taste was more pronounced in sweet and salty intensity ratings. Conclusion: Chemosensory deficits associated with COVID-19 infection were quite frequent among the Greek patients with mild or moderate disease who, in most cases, returned to normal within 4 weeks. However, 1 in 3 patients presented with persistent olfactory and gustatory dysfunction in the short term.

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“…An excellent example of this are the olfactory ERPs now widely used for assessment of olfactory functions, e.g. for medico-legal questions (Hummel et al, 2007, Ren et al, 2012. The method was developed by Kobal and Plattig, 1978, Plattig, 1989, Hummel and Kobal, 2001 In order to measure gustatory ERPs, the same prerequisites apply to the gustatory stimulator as they apply to olfactory stimulators.…”

Section: Q6mentioning

confidence: 98%

A gustatory stimulator

Iannilli

Beger

Fürer

et al. 2015

Journal of Neuroscience Methods

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Intranasal trigeminal chemosensitivity in patients with postviral and post-traumatic olfactory dysfunction

Cited by 22 publications

References 23 publications

Effect of gender on odor identification at different life stages: a meta-analysis

Effect of gender on odor identification at different life stages: a meta-analysis

Short-Term Follow-Up of Self-Isolated COVID-19 Patients with Smell and Taste Dysfunction in Greece: Two Phenotypes of Recovery

A gustatory stimulator

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