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Cited by 128 publications
(97 citation statements)
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References 13 publications
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“…85 There have been 2 trials of intranasal steroids performed exclusively in children: one comparing intranasal corticosteroids versus an oral decongestant 87 and the other comparing intranasal corticosteroids with placebo. 88 These studies showed a greater rate of complete resolution 87 or greater reduction in symptoms in patients receiving the steroid preparation, although the effects were modest. 88 It is important to note that nearly all of these studies (both those reported in children and adults) suffered from substantial methodologic problems.…”
Section: Intranasal Steroidsmentioning
confidence: 97%
See 1 more Smart Citation
“…85 There have been 2 trials of intranasal steroids performed exclusively in children: one comparing intranasal corticosteroids versus an oral decongestant 87 and the other comparing intranasal corticosteroids with placebo. 88 These studies showed a greater rate of complete resolution 87 or greater reduction in symptoms in patients receiving the steroid preparation, although the effects were modest. 88 It is important to note that nearly all of these studies (both those reported in children and adults) suffered from substantial methodologic problems.…”
Section: Intranasal Steroidsmentioning
confidence: 97%
“…88 These studies showed a greater rate of complete resolution 87 or greater reduction in symptoms in patients receiving the steroid preparation, although the effects were modest. 88 It is important to note that nearly all of these studies (both those reported in children and adults) suffered from substantial methodologic problems. Examples of these methodologic problems are as follows: (1) variable inclusion criteria for sinusitis, (2) mixed populations of allergic and nonallergic subjects, and (3) different outcome criteria.…”
Section: Intranasal Steroidsmentioning
confidence: 97%
“…3 Several studies conclude that intranasal corticosteroids (with or without antibiotics) are beneficial in ARS patients and are equally or more effective than antibiotics alone. [4][5][6][7][8] Currently, only one intranasal corticosteroidmometasone furoate nasal spray (MFNS) -is approved for ARS, 9 and this indication is limited to Canada. Fluticasone furoate, an enhanced-affinity glucocorticoid, has been developed as an intranasal spray for the treatment of allergic rhinitis (AR).…”
mentioning
confidence: 99%
“…Intranasal budesonide spray had a modest effect on symptoms only during the second week of therapy. 57 A multicenter, double-blind, randomized, parallel trial evaluating flunisolide spray as an adjunct to oral antibiotic therapy was reported in patients at least 14 years of age. 58 The benefit of flunisolide was marginal and of minimal clinical importance.…”
Section: Adjuvant Therapiesmentioning
confidence: 99%