volume 93, issue 0, P2-P-178 2020
DOI: 10.1254/jpssuppl.93.0_2-p-178
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Abstract: We have recently demonstrated that infusion of eicosapentaenoic acid-derived resolvin E1 (RvE1) into the medial prefrontal cortex (mPFC) exerts antidepressant effects via brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) release and subsequent activation of mechanistic target of rapamycin complex 1 (mTORC1) in a murine lipopolysaccharide (LPS)-induced depression model. In the present study, we examined the roles of BDNF/VEGF release and mTORC1 activation within the mPFC in …

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