Intrameningioma metastasis as first clinical manifestation of occult primary breast carcinoma

Caroli, Emanuela; Salvati, Maurizio; Giangaspero, Felice; Ferrante, Luigi; Santoro, Antonio

doi:10.1007/s10143-005-0395-4

Cited by 65 publications

(68 citation statements)

References 40 publications

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“…3 RCC and meningioma are the most common visceral and intracranial recipients of metastasis, respectively, although the mechanism of tumor-to-tumor metastasis is not well understood. 2,4,5 In theory, both HAB and meningioma are good recipients of RCC because they have abundant vascularization, slow growth and often remain unnoticed for a long time. 2,4,5 Metastatic RCC to HAB of the CNS was first reported in 1992, in a patient with VHL disease.…”

Section: Discussionmentioning

confidence: 99%

“…2,4,5 In theory, both HAB and meningioma are good recipients of RCC because they have abundant vascularization, slow growth and often remain unnoticed for a long time. 2,4,5 Metastatic RCC to HAB of the CNS was first reported in 1992, in a patient with VHL disease. 6 To our knowledge, only 14 patients with metastatic RCC to HAB have been reported, and all patients had been diagnosed with VHL syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…1 Meningioma is the most common CNS tumor to host a metastatic tumor, and breast and lung carcinomas are the most common donor tumors. 2 We report a 38-year-old man with Von Hippel-Lindau (VHL) syndrome who had a haemangioblastoma (HAB) in the medulla oblongata complicated by a metastasis from renal cell carcinoma (RCC). Histologically both HAB and RCC present similar clear cells and highly vascularized stroma.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel–Lindau syndrome

Xiong

Wang

et al. 2010

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel–Lindau syndrome

Xiong

Wang

et al. 2010

Journal of Clinical Neuroscience

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“…Since the first case was described by Berent in 1902, more than 100 intracranial tumors have been reported (3,4,6,12,15). Meningiomas account for about two-thirds of those tumors (15), whereas only six cases of intracranial schwannoma have been reported (6,13,23,25,26).…”

Section: Introductionmentioning

confidence: 96%

Tumor-to-Tumor Metastasis: Lung Adenocarcinoma Metastasizing to Vestibular Schwannoma Suspected on Preoperative [18F]-Fluorodeoxyglucose Positron Emission Tomography Imaging

Fukushima¹,

Ota²,

Mukasa³

et al. 2012

World Neurosurgery

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“…Most papers published on this subject have been case reports or a small case series, [2][3][4][7][8][9][10][11] and the clinical features and distinctive radiological characteristics of this condition have not been described in detail. There are few case reports of cancer metastasizing to an intracranial meningioma; however, only two cases of metastasis to a spinal meningioma appear in the literature.…”

mentioning

confidence: 99%

Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

Okada¹,

Nakamura²,

Koshida³

et al. 2014

The Journal of Spinal Cord Medicine

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Context: Systemic metastasis to a primary tumor of the central nervous system is uncommon. Breast carcinomas metastasizing to a possibly preexisting meningioma in the spine are reported very rarely. Study design: Case report. Findings: A 69-year-old female was referred to us with progressive gait disturbance. She had undergone a total mastectomy for carcinoma of the right breast 11 years previously. A magnetic resonance imaging of the thoracic spine showed an intra-and extradural spinal cord tumor. The patient underwent resection of the tumor via laminectomy from T2 to T4. After the operation, the patient's neurological status improved significantly, and she was able to walk without assistance. Histological examination showed the tumor to be a fibrous-type meningioma within a metastatic breast cancer tumor. The patient underwent 40 Gy radiation treatment for local control of the tumor. However, the tumor recurred locally 7 months after the surgery. The patient died of carcinomatous pleurisy 13 months after the surgery. Conclusion: This case illustrates that a primary meningioma in the thoracic spine can be a recipient of breast cancer metastasis, which may alter the treatment strategy.Keywords: Breast carcinoma, Metastasis, Meningioma, Thoracic spine ContextAdvanced cancer metastases to a central nervous system tumor are rare. When it happens, the metastatic tumor is most often a meningioma.1-11 Several hypotheses explaining the mechanism of distant metastases to a pre-existing central nervous system tumor have been proposed, and include the rich vascularity of the preexisting tumor or hormonal or immunologic factors, but the underlying mechanism remains unclear. Most papers published on this subject have been case reports or a small case series, 2-4,7-11 and the clinical features and distinctive radiological characteristics of this condition have not been described in detail. There are few case reports of cancer metastasizing to an intracranial meningioma; however, only two cases of metastasis to a spinal meningioma appear in the literature. 2,9 Here, we present the very rare case of breast cancer metastasis to a possibly preexisting thoracic meningioma. Case presentationA 69-year-old female was referred to our department with a 1-month history of progressive gait disturbance and back pain. The patient had undergone total mastectomy for carcinoma of the right breast (T2N0M0: stage IIA) 11 years previously. Histological examination had revealed the breast cancer to be invasive ductal carcinoma. Estrogen and progesterone receptors were negative. The patient was treated with four cycles of adjuvant chemotherapy. Seven years after the mastectomy, a chest radiograph revealed a right lung metastasis, and the patient underwent apical segmentectomy to remove the metastatic carcinoma. The lung metastasis had transformed into a metaplastic carcinoma, consisting of malignant bone and cartilage in addition to ordinary ductal carcinoma.

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Intrameningioma metastasis as first clinical manifestation of occult primary breast carcinoma

Cited by 65 publications

References 40 publications

Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel–Lindau syndrome

Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel–Lindau syndrome

Tumor-to-Tumor Metastasis: Lung Adenocarcinoma Metastasizing to Vestibular Schwannoma Suspected on Preoperative [18F]-Fluorodeoxyglucose Positron Emission Tomography Imaging

Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

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