2006
DOI: 10.1001/archderm.142.8.1069-b
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Intralesional Lipolysis With Phosphatidylcholine for the Treatment of Lipomas: Pilot Study

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Cited by 11 publications
(3 citation statements)
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“…Recent observations from our laboratory 10 and others 7,11 suggest that the active component in PC‐containing fat reduction formulations is not PC but rather sodium deoxycholate (DC), the bile salt invariably included in these formulations to emulsify the otherwise self‐aggregating PC molecules. Lipomas injected with DC or the combination of PC and DC showed rapid damage to adipocytes consistent with DC‐mediated membrane destabilization 12–14 . Moreover, in a head‐to‐head clinical trial, DC alone produced a similar reduction in subcutaneous fat pad volume as did a conventional PC/DC formulation, 15 suggesting that PC did not contribute to clinical efficacy.…”
mentioning
confidence: 90%
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“…Recent observations from our laboratory 10 and others 7,11 suggest that the active component in PC‐containing fat reduction formulations is not PC but rather sodium deoxycholate (DC), the bile salt invariably included in these formulations to emulsify the otherwise self‐aggregating PC molecules. Lipomas injected with DC or the combination of PC and DC showed rapid damage to adipocytes consistent with DC‐mediated membrane destabilization 12–14 . Moreover, in a head‐to‐head clinical trial, DC alone produced a similar reduction in subcutaneous fat pad volume as did a conventional PC/DC formulation, 15 suggesting that PC did not contribute to clinical efficacy.…”
mentioning
confidence: 90%
“…Lipomas injected with DC or the combination of PC and DC showed rapid damage to adipocytes consistent with DC-mediated membrane destabilization. [12][13][14] Moreover, in a head-to-head clinical trial, DC alone produced a similar reduction in subcutaneous fat pad volume as did a conventional PC/DC formulation, 15 suggesting that PC did not contribute to clinical efficacy.…”
mentioning
confidence: 93%
“…Ab 2004 gab es die ersten Studien an der Dermatologischen Klinik der Ruhr Universität Bochum zur Behandlung von Lipomen mit PPC-DOC [3,4,5,6,7]. Im Jahr 2006 begann dann eine Grundlagenstudie zur Wirkung der Einzelsubstanzen und ihrer Kombination an der Universität Regensburg, die 2008 publiziert wurde [26,27].…”
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