Intralesional Immunotherapy of Warts With Mumps, Candida, and Trichophyton Skin Test Antigens

Abstract

Background: Warts occur commonly in humans. Destructive modalities are generally the first physicianadministered therapy. Other treatment options include immunotherapy. Intralesional immunotherapy using mumps, Candida, or Trichophyton skin test antigens has proved efficacy in the treatment of warts.Objectives: To determine rates of wart resolution in response to injection of antigen alone, antigen plus interferon alfa-2b, interferon alfa-2b alone, and normal saline; and to compare response according to viral type, major histocompatibility complex antigens, and peripheral blood mononuclear cell proliferation to autologous human papillomavirus antigen before and after injection.

Peripheral blood toll-like receptor 4 correlates response to candida immunotherapy of warts

“…In the present study, significant relation was found between treatment response and younger ages, with no significant relation was found between treatment response and disease duration, sex, and wart site. These results were in agreement with Horn et al () who observed a significant improvement in the response for intralesional immunotherapy in age less than 40 years.…”

Intralesional tuberculin (PPD) versus measles, mumps, rubella (MMR) vaccine in treatment of multiple warts: a comparative clinical and immunological study

“…Despite the absence of a significant correlation between the response and age in the MMR‐treated group, our finding of a significant negative correlation of response with age in the PPD‐treated group denotes that younger patients are more capable of producing an effective immune response to this form of therapy than older ones. This agrees with a previous study using mumps and candida antigens in which younger patients responded better than older ones.…”

Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts

“…One case of recurrence was observed after 2 months of follow-up in G1and no recurrence occurred in G2 or G3. Similar observations of absent or low recurrence rates have been reported by related studies with Candida Ag [ 9 , 18 , 21 , 26 – 28 ] .…”