Intralesional Fluorouracil Injection in Infantile Digital Fibromatosis

Oh, Chang‐Keun; Son, Hyo-Sung; Kwon, Yoo-Wook; Jang, Ho‐Sun; Kwon, Kyung‐Sool

doi:10.1001/archderm.141.5.549

Cited by 41 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides pain with the injection, adverse effects were minimal. Intralesional injections of 5-FU have also been used with success for the treatment of infantile digital fibromatosis, a benign fibrous tumor that arises on the fingers and toes of infants and children, 153 and knuckle pads. 154 …”

Section: -Fluorouracilmentioning

confidence: 99%

Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children

Berman

Viera

Amini

et al. 2008

Journal of Craniofacial Surgery

128

View full text Add to dashboard Cite

Hypertrophic scars and keloids are challenging to manage, particularly as sequelae of burns in children in whom the psychologic burden and skin characteristics differ substantially from adults. Prevention of hypertrophic scars and keloids after burns is currently the best strategy in their management to avoid permanent functional and aesthetical alterations. Several actions can be taken to prevent their occurrence, including parental and children education regarding handling sources of fire and flammable materials, among others. Combination of therapies is the mainstay of current burn scar management, including surgical reconstruction, pressure therapy, silicon gels and sheets, and temporary garments. Other adjuvant therapies such as topical imiquimod, tacrolimus, and retinoids, as well as intralesional corticosteroids, 5-fluorouracil, interferons, and bleomycin, have been used with relative success. Cryosurgery and lasers have also been reported as alternatives. Newer treatments aimed at molecular targets such as cytokines, growth factors, and gene therapy, currently in developing stages, are considered the future of the treatment of postburn hypertrophic scars and keloids in children.

show abstract

Section: -Fluorouracilmentioning

confidence: 99%

Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children

Berman

Viera

Amini

et al. 2008

Journal of Craniofacial Surgery

128

View full text Add to dashboard Cite

show abstract

“…Further studies are needed in order to better establish the dermoscopic characteristics of IDF, thus helping further the diagnostic approach. Few therapeutic approaches have been tried so far other than surgery (7,14,15). Intra-lesional steroids tried in 7 patients, cleared 6 lesions and 1 recurred vs 5/10 treated with surgery (14).…”

Section: Discussionmentioning

confidence: 99%

“…Intra-lesional steroids tried in 7 patients, cleared 6 lesions and 1 recurred vs 5/10 treated with surgery (14). Intra lesional fluorouracil cleared completely a lesion in 1 patient with good cosmetic results (15). Topical steroids and imiquimod (6) had no therapeutic effect with the latter provoking significant skin irritation leading to its interruption.…”

Section: Discussionmentioning

confidence: 99%

Infantile digital fibromatosis: case based review and first reported dermoscopic picture

P¹

2016

cderm

View full text Add to dashboard Cite

SummaryInfantile Digital Fibromatosis (IDF) is a relatively not so rare benign tumor of soft tissue origin that occurs mostly in infancy. In this study we present the case of an 11-month-old male infant diagnosed with a solitary IDF of the 4 th finger of right hand. The clinical, dermoscopic, surgical, ultrasound and histopathologic features of the disease are presented; the differential diagnoses, therapeutic procedures and prognosis all are described through a short literature review. In this case report we present for the first time the dermoscopic features of IDF followed by ultrasound correlation. An excisional biopsy for diagnostic and therapeutic reasons was performed which resulted in an improvement of the functionality of the finger.KEY WORDS: infantile digital fibromatosis; benign tumor infancy; Reye's tumor.

show abstract

“…29 They found that intralesional steroids had a lower recurrence rate with fewer complications, but because of the low patient volume (10 surgical interventions and 7 steroid interventions) the study lacked statistical significance. Oh et al 30 attempted to treat this lesion with 5 monthly intralesional injections of fluorouracil using undiluted fluorouracil (50 mg/dL) with a 30-gauge needle without any local or general anesthesia totaling 10 mg (0.2 mL) of fluorouracil injected at 2 or 3 sites. 30 They found a partial response after just 1 injection and that the lesion eventually regressed entirely after 5 injections, with no recurrence after 2 years.…”

Section: Treatmentmentioning

confidence: 99%

“…Oh et al 30 attempted to treat this lesion with 5 monthly intralesional injections of fluorouracil using undiluted fluorouracil (50 mg/dL) with a 30-gauge needle without any local or general anesthesia totaling 10 mg (0.2 mL) of fluorouracil injected at 2 or 3 sites. 30 They found a partial response after just 1 injection and that the lesion eventually regressed entirely after 5 injections, with no recurrence after 2 years. Laskin et al 5 concluded, based on their study involving the largest number of infantile digital fibroma cases, that the best course of action is to have clinical observation after an initial biopsy diagnosis, with additional intervention reserved for lesions causing functional impairment, showing continued growth, or creating cosmetic concerns.…”

Section: Treatmentmentioning

confidence: 99%

Infantile Digital Fibroma: A Rare Fibromatosis

Marks

Ewart²

2016

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Infantile digital fibroma is a rare benign lesion that usually occurs during the first 2 years of life. It can be multiple, but it is usually a single lesion. If it grows large enough it can cause joint deformities or interfere with everyday activities. Microscopically, the neoplastic cells usually have inclusion bodies that are best highlighted with a Masson trichrome stain but can often be seen on hematoxylin-eosin staining. Treatment for this entity is usually watchful waiting because of its ability to spontaneously regress, but excision is recommended if the lesion is symptomatic. More recently, fluorouracil or injectable steroids have shown great promise in inducing regression without the complications that accompany surgery.

show abstract

Intralesional Fluorouracil Injection in Infantile Digital Fibromatosis

Cited by 41 publications

References 14 publications

Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children

Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children

Infantile digital fibromatosis: case based review and first reported dermoscopic picture

Infantile Digital Fibroma: A Rare Fibromatosis

Contact Info

Product

Resources

About