Intralesional Fluorouracil/Epinephrine Injectable Gel for Treatment of Condylomata Acuminata

Swinehart, James M.; Sperling, Malcolm; Phillips, Stephen J.; Kraus, Stephen J.; Gordon, S.; McCarty, James; Webster, Guy F.; Skinner, Robert B.; Korey, Andrew; Orenberg, Elaine K.

doi:10.1001/archderm.1997.03890370073011

Cited by 23 publications

(7 citation statements)

References 23 publications

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“…Fluorouracil is an antimetabolic drug that inhibits DNA and RNA synthesis and may also function as an immunostimulatory drug 5 . Therapeutic results with topical 5‐FU were significantly better than with the placebo cream in the treatment of verrucae.…”

Section: Discussionmentioning

confidence: 99%

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Intralesional 5‐fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: a prospective placebo‐controlled, single‐blind randomized study

Iscimen

Aydemir

Göksügür

et al. 2004

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

“…To our knowledge there is no reported use of intralesional 5‐FU in the treatment of viral warts, except one report of a fairly complex technique in condylomata accuminata. Swinehart et al 5 . used fluorouracil in the treatment of condylomata acuminata as a gel mixture.…”

Section: Discussionmentioning

confidence: 99%

Intralesional 5‐fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: a prospective placebo‐controlled, single‐blind randomized study

Iscimen

Aydemir

Göksügür

et al. 2004

Acad Dermatol Venereol

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“…Healing rates as high as 36–70% have been reported with topical podophyllotoxin [8, 9, 10]and 60–70% with repeated cryotherapy [11], trichloroacetic acid [11]and intralesional 5-fluorouracil [12], respectively. Imiquimod yields remission rates between 35 and 50% after 16 weeks of 3 times per week application [13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

CO<sub>2</sub> Laser Surgery for Extensive, Cauliflower-Like Anogenital Condylomata acuminata: Retrospective Long-Term Study on 19 HIV-Positive and 45 HIV-Negative Men

Carrozza¹,

Merlani

Burg³

et al. 2002

Dermatology

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Background: Extensive ‘cauliflower-like’ condyloma acuminatum (CA) in males is commonly treated with CO₂ laser surgery or with electrosurgery. Studies on the long-term outcome in this specific situation are scarce. Objectives: To determine the cure and recurrence rate in relation to the HIV status and endoanal location of lesions. To determine the complication rate and patient satisfaction. Methods: Questionnaire-based retrospective long-term study on 64 consecutive men (answer rate 60% or 64/107 addressed persons). The mean follow-up was 25 months (range 7–75). Results: The overall cure rate after 1 intervention was 67%. The cure rate in HIV-positive versus HIV-negative patients was 58 versus 71% (odds ratio = 1.79; p = 0.38). Endoanal versus perianal location was associated with a cure rate of 56 versus 84% (odds ratio = 4.06; p = 0.03). After a second treatment session, the cure rate increased to 79% or higher in all subgroups. Painful defecation for an average of 4–5 weeks was the main postoperative complaint. Severe complications were not seen or reported. Conclusions: The CO₂ laser is a valuable and safe treatment to debulk extensive ‘cauliflower- like’ anogenital CA in males. The healing rate in HIV-positive patients is not significantly lower than in HIV-negative patients. Endoanal location of lesions is a risk factor for recurrence.

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“…Swinehart and colleagues 18 and Kontochristopoulos and colleagues 19 used intralesional 5‐FU for the treatment of condylomata acuminata and keloids. Both of them reported severe pain following the injection of 5‐FU alone.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Common Warts with an Intralesional Mixture of 5-Fluorouracil, Lidocaine, and Epinephrine: A Prospective Placebo-Controlled, Double-Blind Randomized Trial

2008

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Intralesional Fluorouracil/Epinephrine Injectable Gel for Treatment of Condylomata Acuminata

Cited by 23 publications

References 23 publications

Intralesional 5‐fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: a prospective placebo‐controlled, single‐blind randomized study

Intralesional 5‐fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: a prospective placebo‐controlled, single‐blind randomized study

CO<sub>2</sub> Laser Surgery for Extensive, Cauliflower-Like Anogenital Condylomata acuminata: Retrospective Long-Term Study on 19 HIV-Positive and 45 HIV-Negative Men

Treatment of Common Warts with an Intralesional Mixture of 5-Fluorouracil, Lidocaine, and Epinephrine: A Prospective Placebo-Controlled, Double-Blind Randomized Trial

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