Intraindividual variability of striatal 1H-MRS brain metabolite measurements at 3 T

Soreni, Noam; Noseworthy, Michael D.; Cormier, Toni; Oakden, Wendy; Bells, Sonya; Schachar, Russell

doi:10.1016/j.mri.2005.10.027

Cited by 37 publications

(40 citation statements)

References 22 publications

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“…Soreni et al 149 examined the intraindividual variability in the striatum at 3 T using a short TE PRESS sequence. They found, in accord with previous studies, 150 -152 that there was an effect of laterality on the MR spectra.…”

Section: Reproducibility Of Mrs Studies Of Normal Controlsmentioning

confidence: 99%

Recent Advances in Magnetic Resonance Neurospectroscopy

Rosen

Lenkinski

2007

Neurotherapeutics

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Summary:Over the past two decades, proton magnetic resonance spectroscopy (proton MRS) of the brain has made the transition from research tool to a clinically useful modality. In this review, we first describe the localization methods currently used in MRS studies of the brain and discuss the technical and practical factors that determine the applicability of the methods to particular clinical studies. We also describe each of the resonances detected by localized solvent-suppressed proton MRS of the brain and discuss the metabolic and biochemical information that can be derived from an analysis of their concentrations. We discuss spectral quantitation and summarize the reproducibility of both single-voxel and multivoxel methods at 1.5 and 3-4 T. We have selected three clinical neurologic applications in which there has been a consensus as to the diagnostic value of MRS and summarize the information relevant to clinical applications. Finally, we speculate about some of the potential technical developments, either in progress or in the future, that may lead to improvements in the performance of proton MRS.

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Section: Reproducibility Of Mrs Studies Of Normal Controlsmentioning

confidence: 99%

Recent Advances in Magnetic Resonance Neurospectroscopy

Rosen

Lenkinski

2007

Neurotherapeutics

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“…For comparison, CV's from repeated bulk phantom measurements, which do not address localization, typically range between 2 to 4% [13][14][15], with accuracies around 6% [13]. This accuracy would deteriorate rapidly if localization became critical because OV contamination can be high [32,44].…”

Section: Accuracymentioning

confidence: 99%

“…Localized magnetic resonance spectroscopy (LMRS), which uses gradient-enabled imaging systems, is increasingly used both in basic and clinical assays including qualitative and quantitative compositional, temperature, and pH measurements [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Kreiss [16] summarized the main aspects of LMRS, including spectral artifacts, systematic errors, and general criteria for ensuring spectral quality.…”

Section: Introductionmentioning

confidence: 99%

Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol

O’Connor

Gropler

Peterson

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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Localized magnetic resonance spectroscopy (LMRS) promises a powerful noninvasive means to determine myocardial triacylglycerol (TAG) in a clinical setting. Here, the linearity, specificity, robustness, precision, and accuracy, of an ex vivo mouse-heart LMRS TAG assay are assessed by quantifying the spatial, spectral, and relaxation induced uncertainties. The protocol, which is based on localization by adiabatic selective refocusing (LASER) using frequency offset corrected inversion pulses (FOCI), alternating gradient polarity, and simple post-processing, is shown to have good characteristics. The presented protocol has a benchmark, phantom-based, accuracy of 3%, and when applied to ex vivo mouse-hearts the accuracy is 6%, making the LMRS assay comparable to the typical destructive bioanalytical assay.

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confidence: 99%

“…One of these methods, in vivo single-voxel 1 H-MRS, is now a widely available method on MRI scanners used for experimental and clinical studies [24]. 1 H-MRS can measure the levels of several brain metabolites, including creatine (Cr)/phosphocreatine (PCr), choline-containing compound (Cho), and Nacetyl-aspartate (NAA) [24]. In this respect, MRS can offer a noninvasive and efficient means for performing functional and metabolic/biochemical evaluation of the brain, which may be useful in the diagnosis and follow-up of metabolic and degenerative diseases [4].…”

mentioning

confidence: 99%

Differential Neurochemical Responses of the Canine Striatum with Pentobarbital or Ketamine Anesthesia: A 3T Proton MRS Study

Lee

Kim

Woo

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Although anesthetic agents are known to affect cerebral metabolism, pentobarbital and ketamine have been widely used for animal imaging studies. The purpose of this study is to evaluate alterations in striatum metabolites in dogs between anesthetized with pentobarbital and with ketamine in proton magnetic resonance spectroscopy ( 1 H-MRS).1 H-MRS was performed to ten healthy adult beagle dogs (9-11 kg) at a field strength of 3 T in order to identify metabolic changes after pentobarbital or ketamine administration in the striatum in vivo. Ten dogs were divided into 2 groups as follows: 5 as the pentobarbital-administered group (P group) and 5 as the ketamine-administered group (K group). We found that levels of Glx of the P group was significantly lower than that of the K group (6.90  0.99 (SD) vs 9.77  1.14 in 5 dogs, p= 0.003). In addition, the P group also has lower levels of Cr (6.29  0.44 vs 7.89  0.91 in 5 dogs, p=0.009) and NAA (5.02  0.65 vs 6.45  1.13 in 5 dogs, p=0.041) compared to the K group. However, there were no significant difference between the P group and the K group in striatal levels of Cho and Ins (p>0.1). We demonstrated that MRS-measured metabolites in the specific regions of the brain can be influenced by anesthetic agents.

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Intraindividual variability of striatal 1H-MRS brain metabolite measurements at 3 T

Cited by 37 publications

References 22 publications

Recent Advances in Magnetic Resonance Neurospectroscopy

Recent Advances in Magnetic Resonance Neurospectroscopy

Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol

Differential Neurochemical Responses of the Canine Striatum with Pentobarbital or Ketamine Anesthesia: A 3T Proton MRS Study

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