Intrahepatic arterial administration of 4′epidoxorubicin (epirubicin) in advanced cancer patients. A pharmacokinetic study

Clinical Pharmacokinetics of Epirubicin

“…After intravenous administration, less than 20% of the injected dose is recovered in urine, either as unchanged drug or as epirubicinol and glucuronide metabolites (Camaggi et al 1988;Mross et al 1988;Robert et al 1985;Vrignaud et al 1985). Cumulative biliary excretion was approximately 40% over a 3-day period (Camaggi et al 1986). In total, 50% of an epirubicin dose is eliminated within 4 days, compared with 7 days for elimination of 50% of a dose of doxorubicin.…”

“…Several investigators have studied intrahepatic administration of epirubicin through the hepatic artery (Eksborg et al 1986a;Pannuti et al 1986;Strocchi et al 1985). After intrahepatic administration, systemic drug concentrations were significantly lower than after intravenous administration and the total body clearance of the drug was 1.5-to 2-fold higher.…”

Clinical Pharmacokinetics of Epirubicin

“…After intravenous administration, less than 20% of the injected dose is recovered in urine, either as unchanged drug or as epirubicinol and glucuronide metabolites (Camaggi et al 1988;Mross et al 1988;Robert et al 1985;Vrignaud et al 1985). Cumulative biliary excretion was approximately 40% over a 3-day period (Camaggi et al 1986). In total, 50% of an epirubicin dose is eliminated within 4 days, compared with 7 days for elimination of 50% of a dose of doxorubicin.…”

“…Several investigators have studied intrahepatic administration of epirubicin through the hepatic artery (Eksborg et al 1986a;Pannuti et al 1986;Strocchi et al 1985). After intrahepatic administration, systemic drug concentrations were significantly lower than after intravenous administration and the total body clearance of the drug was 1.5-to 2-fold higher.…”

Clinical Pharmacokinetics of Epirubicin

“…After intravenous administration, less than 20% of the injected dose is recovered in urine, either as unchanged drug or as epirubicinol and glucuronide metabolites (Camaggi et al 1988;Mross et al 1988;Robert et al 1985;Vrignaud et al 1985). Cumulative biliary excretion was approximately 40% over a 3-day period (Camaggi et al 1986). In total, 50% of an epirubicin dose is eliminated within 4 days, compared with 7 days for elimination of 50% of a dose of doxorubicin.…”

“…Several investigators have studied intrahepatic administration of epirubicin through the hepatic artery (Eksborg et al 1986a;Pannuti et al 1986;Strocchi et al 1985). After intrahepatic administration, systemic drug concentrations were significantly lower than after intravenous administration and the total body clearance of the drug was 1.5-to 2-fold higher.…”

Clinical Pharmacokinetics of Epirubicin

“…After intravenous administration, less than 20% of the injected dose is recovered in urine, either as unchanged drug or as epirubicinol and glucuronide metabolites (Camaggi et al 1988;Mross et al 1988;Robert et al 1985;Vrignaud et al 1985). Cumulative biliary excretion was approximately 40% over a 3-day period (Camaggi et al 1986). In total, 50% of an epirubicin dose is eliminated within 4 days, compared with 7 days for elimination of 50% of a dose of doxorubicin.…”

“…Several investigators have studied intrahepatic administration of epirubicin through the hepatic artery (Eksborg et al 1986a;Pannuti et al 1986;Strocchi et al 1985). After intrahepatic administration, systemic drug concentrations were significantly lower than after intravenous administration and the total body clearance of the drug was 1.5-to 2-fold higher.…”