Intracranial Multifocal Dural Involvement in Multiple Myeloma: Case Report and Review of the Literature

Méndez, Carlos E.; Hwang, Becky J.; Destian, Sylvie; Mazumder, Amitabha; Jagannath, Sundar

doi:10.3816/clml.2010.n.035

Cited by 21 publications

(24 citation statements)

References 14 publications

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“…Improved survival had been reported in some studies with patients receiving combined modality treatment; however, the results have not been uniform [19]. The use of older generation drugs that may cross the BBB such as doxorubicin, cyclophosphamide, and melphalan were mostly unsuccessful in managing LMM [5,51]. In contrast, these agents have been successful in managing systemic myeloma and other leukemias with CNS involvement.…”

Section: Chemotherapymentioning

confidence: 98%

“…Intrathecal (IT) chemotherapy, systemic chemotherapy, cranial irradiation, surgical intervention, and stem cell transplant (SCT) have been used in the past to treat LMM. Certain characteristics that may affect the overall outcome of the disease include age, performance status of the patient at LMM diagnosis, comorbidities, severity of CNS involvement, and previous chemotherapy exposure [11,51].…”

Section: Treatment Of Lmmmentioning

confidence: 99%

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Retracted: Overview of recent trends in diagnosis and management of leptomeningeal multiple myeloma

et al. 2014

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Neurological complications related to multiple myeloma (MM) are not uncommon; however, direct involvement of the central nervous system (CNS) is extremely rare and represents a diagnostic and therapeutic challenge. Significant survival difference has been noted with the introduction of novel therapy in patients with MM, but their effect on the incidence and their use for management of leptomeningeal myeloma (LMM) is uncertain. Analysis of published data demonstrates its recent increased incidence, median time to CNS presentation, and slight improvement in median survival after diagnosis of LMM. Less common MM isotypes have been overrepresented in LMM. CNS relapse occurred mostly in patients with Durie-Salmon stage III MM. Despite treatments, standard or experimental, the survival rates of LMM remain dismal. Monitoring high risk patients closely, even after achieving complete remission, may be useful in early detection of LMM. As we gain better understanding of LMM, we recommend that future research and clinical care focus on earlier diagnosis and development of more efficient CNS-directed therapy to improve survival in this patient population.

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Section: Chemotherapymentioning

confidence: 98%

Section: Treatment Of Lmmmentioning

confidence: 99%

Retracted: Overview of recent trends in diagnosis and management of leptomeningeal multiple myeloma

et al. 2014

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“…Brak plazmocytów w pmr może mieć związek z lokalizacją nacieku w obrębie OUN, np. śródmózgowa lub jako izolowane zmiany opony twardej [10]. Stężenie białka w płynie mózgowo-rdzeniowym jest niższe niż we krwi.…”

Section: Diagnostykaunclassified

“…Znaleziono pojedyncze doniesienia sugerujące korzystny wpływ chemioterapii systemowej w obrębie OUN. Przykładem może by przypadek opisany przez Mendeza i wsp., w którym uzyskano przejściową poprawę kliniczną i laboratoryjną po 2 kursach VD-PACE [10]. Talidomid przenika do OUN, znany jest na przykład jego efekt sedatywny [7].…”

Section: Leczenieunclassified

Zajęcie ośrodkowego układu nerwowego w przebiegu szpiczaka plazmocytowego – opis przypadku i przegląd literatury

Jurczyszyn¹,

Olszewska-Szopa²,

Fornagiel³

et al. 2015

Acta Haematologica Polonica

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a c t a h a e m a t o l o g i c a p o l o n i c a 4 6 ( 2 0 1 5 ) 2 4 2 -2 4 7 i n f o r m a c j e o a r t y k u l e Historia artykułu: Słowa kluczowe: szpiczak ośrodkowy układ nerwowy diagnostyka leczenie Słowa kluczowe: Myeloma Central nervous system Diagnosis Treatment a b s t r a c t In multiple myeloma extramedullary involvement occurs in 13% of patients. Central nervous system (CNS) involvement is extremely rare and comprises 1% of cases. Review of literature shows only limited data on this subject and consists mostly of few case reports. Scarce knowledge about CNS involvement in the course of multiple myeloma makes its diagnosis and treatment very difficult and challenging. The authors describe a clinical case which illustrates the problem from a clinician point of view. Furthermore, we analyzed the available data from literature and summarized the current state of knowledge on diagnosis, potential prognostic factors, treatment and prognosis in CNS myeloma involvement.

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“…[1][2][3] While both the central and peripheral nervous systems may be affected, involvement of the central nervous system (CNS) is rare and the prognosis is usually quite poor. 2 Usually, CNS involvement is observed in cases of established residual MM or during a subsequent relapse. 3 This case report describes a patient with MM which manifested initially with cranial diabetes insipidus.…”

mentioning

confidence: 99%

A Case of Multiple Myeloma Presenting with Diabetes Insipidus

Paul¹,

Ruia²,

Saha³

et al. 2017

SQUMJ

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Multiple myeloma (MM) can present with involvement of the central nervous system in the form of nerve palsy, plasma cell masses or, rarely, with endocrinological effects due to involvement of the pituitary gland. Usually, in such cases, the disease has a rapid progression and poor prognosis. We report a 52-year-old man who was admitted to the Kolkata Medical College, Kolkata, India, in 2016 with a prolonged low-grade fever and hypernatremia. Shortly afterwards, the patient began to complain of increased urinary frequency and drowsiness. The hypernatremia was treated with intranasal desmopressin and free water replacement. Serum protein electrophoresis and an immunofixation study revealed an immunoglobulin G-κ monoclonal band. Magnetic resonance imaging of the pituitary gland revealed the absence of a posterior bright spot and spotty infiltration of the pituitary fossa. A bone marrow biopsy confirmed a diagnosis of cranial diabetes insipidus due to posterior pituitary MM infiltration.

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Intracranial Multifocal Dural Involvement in Multiple Myeloma: Case Report and Review of the Literature

Cited by 21 publications

References 14 publications

Retracted: Overview of recent trends in diagnosis and management of leptomeningeal multiple myeloma

Retracted: Overview of recent trends in diagnosis and management of leptomeningeal multiple myeloma

Zajęcie ośrodkowego układu nerwowego w przebiegu szpiczaka plazmocytowego – opis przypadku i przegląd literatury

A Case of Multiple Myeloma Presenting with Diabetes Insipidus

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