Intracranial Blood Flow in Dementia Paralytica, Cerebral Atrophy and Schizophrenia

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

“…The genetic defects occurring in AD can facilitate infection as well [for a review see 86]. Spirochetal infections cause cerebral hypoperfusion [ 188 - 190 ], cerebrovascular lesions and severely disturbed cortical capillary network [ 29 , 191 , 192 ], which are also important factors in the pathogenesis of AD [ 193 - 199 ]. As in AD, mixed forms of dementia due to cortical atrophy and vascular lesions frequently occur in neurospirochetoses [ 29 , 63 ], further strengthening the coherence of the association.…”

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

“…The genetic defects occurring in AD can facilitate infection as well [for a review see 86]. Spirochetal infections cause cerebral hypoperfusion [ 188 - 190 ], cerebrovascular lesions and severely disturbed cortical capillary network [ 29 , 191 , 192 ], which are also important factors in the pathogenesis of AD [ 193 - 199 ]. As in AD, mixed forms of dementia due to cortical atrophy and vascular lesions frequently occur in neurospirochetoses [ 29 , 63 ], further strengthening the coherence of the association.…”

Cerebral Blood Flow and Oxygen Consumption in Neurosyphilis

“…A diminution in total intracranial blood flow has been found in severely demented patients with general paresis (2), but the method used is now believed to yield abnormally low values. It very probably gives a correct indication, however, of the direction of change in flow.…”

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

“…The genetic defects occurring in AD can facilitate infection as well [for a review see 86]. Spirochetal infections cause cerebral hypoperfusion [ 188 - 190 ], cerebrovascular lesions and severely disturbed cortical capillary network [ 29 , 191 , 192 ], which are also important factors in the pathogenesis of AD [ 193 - 199 ]. As in AD, mixed forms of dementia due to cortical atrophy and vascular lesions frequently occur in neurospirochetoses [ 29 , 63 ], further strengthening the coherence of the association.…”

Cerebral Blood Flow and Oxygen Consumption in Neurosyphilis

“…A diminution in total intracranial blood flow has been found in severely demented patients with general paresis (2), but the method used is now believed to yield abnormally low values. It very probably gives a correct indication, however, of the direction of change in flow.…”

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

“…The genetic defects occurring in AD can facilitate infection as well [for a review see 86]. Spirochetal infections cause cerebral hypoperfusion [ 188 - 190 ], cerebrovascular lesions and severely disturbed cortical capillary network [ 29 , 191 , 192 ], which are also important factors in the pathogenesis of AD [ 193 - 199 ]. As in AD, mixed forms of dementia due to cortical atrophy and vascular lesions frequently occur in neurospirochetoses [ 29 , 63 ], further strengthening the coherence of the association.…”

Cerebral Blood Flow and Oxygen Consumption in Neurosyphilis

“…A diminution in total intracranial blood flow has been found in severely demented patients with general paresis (2), but the method used is now believed to yield abnormally low values. It very probably gives a correct indication, however, of the direction of change in flow.…”