J. Neurosci. Res. volume 87, issue 1, P26-33 2009 DOI: 10.1002/jnr.21817 View full text
Chia-Ron Yang, Robert K. Yu

Abstract: The present investigation examined the neuroprotective benefits for combined trehalose administration with C17.2 neural stem cell transplantation in a transgenic mouse model of Huntington’s disease (HD), R6/2. C17.2 neural stem cells have the potential of differentiating into a neuronal phenotype in vitro and have been shown to be effective in the treatment of a variety of lysosomal lipid storage disorders in the nervous system. In this study, we transplanted these cells into the lateral ventricle of R6/2 tra…

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