Intracerebral Hemorrhage: Pathology of Selected Topics

García, Julio Herrero; Ho, Khang-Loon; Caccamo, Darío V.

doi:10.1016/b978-0-7506-9308-0.50009-9

Cited by 28 publications

(16 citation statements)

References 68 publications

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“…1 Although hematomas in the cortex are amenable to surgical therapy, 2 they remain a significant management problem perhaps because the blood itself has adverse effects beyond its space-occupying effect. Several animal models of intracerebral hemorrhage have been developed, [3][4][5][6] and experiments indicate that space-occupying effect, brain edema, ischemia, and neurotoxicity might all be involved in the brain damage that follows hemorrhage.…”

mentioning

confidence: 99%

Intracortical Hemorrhage Injury in Rats

Xue

Bigio

2000

Stroke

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Background and Purpose-Intracerebral hemorrhage is associated with stroke and head trauma. The purposes of this study were to investigate the effect of intracortical injections of autologous whole blood and blood components on inflammatory cell infiltration and brain cell death and to determine if nonhemorrhagic lesions differ in these respects. Methods-Eighty-seven adult rats were subjected to intracortical injections of autologous whole blood or allogeneic plasma, erythrocytes, leukocytes, "activated" leukocytes, and serum. Injections of saline or mineral oil were controls. Blood injections were compared with cortical freeze injury and pial devascularization. Rats were perfusion-fixed 48 hours after injection or lesioning. Eosinophilic neurons, TUNEL-positive cells, brain damage area, infiltrating neutrophils, and CD8a-immunoreactive lymphocytes were quantified. Results-Damage area, dying cells, and inflammatory infiltrate were significantly greater after autologous whole blood, leukocyte, and "activated" leukocyte injections than injection of other fractions. Conclusions-These results suggest that extravasated whole blood causes a greater degree of cortical cell death and inflammation than ischemic lesions of similar size. Leukocytes "activated" by systemic illness might exacerbate the injury. Secondary hemorrhagic phenomena suggest that the harmful effect is directed toward both brain cells and the vasculature. Further studies are required to delineate the mechanism(s).

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confidence: 99%

Intracortical Hemorrhage Injury in Rats

Xue

Bigio

2000

Stroke

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“…For example, in a rat model of ICH brain edema peaks at day 3 or 4 post-ICH before decreasing slowly (Enzmann et al 1981; Tomita et al 1994; Xi et al 1998a). In large animal models (e.g., pig), perihematomal edema is located mainly within the white matter (Garcia et al 1994; Tomita et al 1994). …”

Section: Natural History Of Ichmentioning

confidence: 99%

Progress in translational research on intracerebral hemorrhage: Is there an end in sight?

Strahle

Hua

et al. 2014

Progress in Neurobiology

133

107

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Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which specific therapies and treatments remain elusive. To address this, many recent experimental and translational studies of ICH have been conducted, and these have led to several ongoing clinical trials. This review focuses on the progress of translational studies of ICH including those of the underlying causes and natural history of ICH, animal models of the condition, and effects of ICH on the immune and cardiac systems, among others. Current and potential clinical trials also are discussed for both ICH alone and with intraventricular extension.

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“…The relationship between the development of hemorrhagic infarction and parenchymal hematoma is not at all clear. 8…”

Section: Hemorrhage Into Embolic Brain Infarcts Caplanmentioning

confidence: 99%