Intracerebral Cystic Meningioma —Case Report—

Shimizu, Katsuyoshi; Furuhata, Shigeru; Sasai, Shin-ya; Tominaga, Susumu; Takamiya, Yoshiaki

doi:10.2176/nmc.39.530

Cited by 11 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, 2 of our MA-M cases were primarily intracerebral. Intracerebral meningiomas, with or without an MA-like component, have been previously reported but are extraordinarily rare (35,42,47,52,66,69,72,75,78). In the current cases, there was some overlap between MA-M and highly cellular MA alone (eg, Figure 5D).…”

Section: The Ma Component Of Ma-m Is Neoplastic In Most Cases Based mentioning

confidence: 46%

Insights into Meningioangiomatosis with and without Meningioma: A Clinicopathologic and Genetic Series of 24 Cases with Review of the Literature

et al. 2006

View full text Add to dashboard Cite

Meningioangiomatosis (MA) is a rare seizure-associated lesion of presumed hamartomatous or developmental origin. It is occasionally combined with a neoplasm, most commonly meningioma (MA-M). In the current study, we examined 24 cases (14 pure MA, 10 MA-M) using immunohistochemistry for merlin, protein 4.1 B, progesterone receptor (PR), and MIB-1, as well as FISH for NF2 and 4.1B gene dosages. Nine cases of MA-M (90%) had gene deletions (NF2/4.7B), protein losses (merlin/protein 4.1B), and/or PR positivity, with a similar or identical phenotype in both components. No PR positivity or gene deletions were seen in pure MAs, though merlin and/or protein 4.1B were immunonegative in six cases. Our data suggest that in most MA-Ms, the MA component is neoplastic, likely representing an exuberant perivascular pattern of spread from the meningioma, rather than an underlying hamartoma. This pattern of spread may be facilitated by meningiomas that are predominantly leptomeningeal or intracerebral in origin. It remains important to distinguish this pattern from true brain invasion, given the more ominous prognostic significance of the latter. In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories.

show abstract

Section: The Ma Component Of Ma-m Is Neoplastic In Most Cases Based mentioning

confidence: 46%

Insights into Meningioangiomatosis with and without Meningioma: A Clinicopathologic and Genetic Series of 24 Cases with Review of the Literature

et al. 2006

View full text Add to dashboard Cite

show abstract

“…31) Several cases involved the MCA branches or had feeding arteries of the MCA, and the mass was buried in the sulcus in operative findings. 16,27,31,32) However, the tumor was embedded in the brain parenchyma in other cases. 10,13) In the present case, we found the tumor after making a cortical incision buried in the brain parenchyma.…”

Section: Discussionmentioning

confidence: 91%

“…32) A total of 23 cases of intraparenchymal meningiomas have been reported including the present case (Table 1). 4,5,[10][11][12][13][14][15][16][18][19][20][24][25][26][27][28][29]31,32) Eighteen patients were aged from 0 to 19 years, and 15 were aged 14 years or younger, so the incidence of pediatric intraparenchymal meningioma is higher than adults. There were 10 males and 10 females, but 8 males and 5 females were aged from 0 to 14 years, indicating male predominance.…”

Section: Discussionmentioning

confidence: 99%

Intraparenchymal Meningioma in a Child -Case Report-

Shimbo

Kato

Takeda

et al. 2011

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 10-year-old boy presented with an intraparenchymal meningioma, which had no attachment to the dura, manifesting as grand-mal seizure. Neurological examination showed no abnormalities. Magnetic resonance (MR) imaging revealed a round, well demarcated mass in the left frontal lobe, which was homogeneously enhanced. The tumor appeared to be intraaxial and caused marked peritumoral white matter edema. At operation, the mass was totally embedded in the frontal lobe and gross total resection was accomplished. The histological diagnosis was meningothelial meningioma with chordoid components in World Health Organization grade I. His postoperative course was uneventful and postoperative MR imaging revealed no residual tumor. Intraparenchymal meningioma should be considered in the differential diagnosis of an intraaxial lesion in a child.

show abstract

“…To our knowledge, only 17 cases of intraparenchymal or subcortical meningiomas have been reported in the literature. Interestingly, four reported intraparenchymal meningiomas were associated with cysts 16–19 . The pathogenesis of cyst formation in intraparechymal meningiomas is also uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, four reported intraparenchymal meningiomas were associated with cysts. [16][17][18][19] The pathogenesis of cyst formation in intraparechymal meningiomas is also uncertain. The histologic subtypes of meningiomas were noted in these four cases.…”

Section: Discussionmentioning

confidence: 99%

Intraparenchymal cystic chordoid meningioma: A case report and review of the literature

Zhao¹,

Yang²,

Tian³

et al. 2011

Neuropathology

View full text Add to dashboard Cite

Meningiomas usually present as benign tumors corresponding to WHO grade I. The development of the intraparenchymal chordoid variant of meningiomas with cyst formation in the CNS is extremely rare. We report a case of cystic chordoid meningioma in a middle-aged man occurring in the brain parenchyma of the left temporal region. The tumor exhibited a marked peritumoral cyst, with contrast enhancement on MRI in accordance with type 2 of Zee's classification of cystic meningioma. Histologically, the tumor displays a typical chordoid structure with trabeculae or cords of eosinophilic vaculoated cells in the abundant mucoid matrix. Tumor cells are diffusely positive for epithelial membrane antigen (EMA), vimentin and focally positive for D2-40, but lack immunoreactivity for cytokeratin (CK) and GFAP. MIB-1 labeling is low, focally accounting for 2% of the tumor. A diagnosis of primary intraparenchymal cystic chordoid meningioma (WHO grade II) was made. There was no evidence of tumor recurrence during the postoperative 6-month follow-up period. To our knowledge, there is no report describing the radiological and histological characteristics of cystic chordoid meningioma entirely presenting in the brain parenchyma. In addition, the biological behavior and histological differential diagnoses of this tumor are discussed.

show abstract

Intracerebral Cystic Meningioma —Case Report—

Abstract: A 46-year

Cited by 11 publications

References 13 publications

Insights into Meningioangiomatosis with and without Meningioma: A Clinicopathologic and Genetic Series of 24 Cases with Review of the Literature

Insights into Meningioangiomatosis with and without Meningioma: A Clinicopathologic and Genetic Series of 24 Cases with Review of the Literature

Intraparenchymal Meningioma in a Child -Case Report-

Intraparenchymal cystic chordoid meningioma: A case report and review of the literature

Contact Info

Product

Resources

About