ABSTRACTExperiments have been carried out to determine whether intracellular transport of pancreatic secretory proteins is obligatorily coupled to protein synthesis or whether it is a separable process which can be independently regulated. To this intent, guinea pig pancreatic slices were pulse labeled with leucine-3H for 3 rain and incubated post-pulse for 37 rain in chase medium containing cycloheximide up to concentrations sufficient to inhibit protein synthesis by 98 %. In controls, newly synthesized secr…
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