J. Neurosci. Res. volume 87, issue 6, P1449-1461 2009 DOI: 10.1002/jnr.21959 View full text
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Ana Gabriela Henriques, Sandra Isabel Vieira, Maria Elena Crespo-López, Márcio A. Guiomar de Oliveira, Edgar F. da Cruz e Silva, Odete A.B. da Cruz e Silva

Abstract: Amyloid beta (Abeta) contributes to neurodegeneration in Alzheimer's disease and provides a close association between molecular events and pathology, although the underlying molecular mechanisms are unclear. In the work described here, Abeta did not induce amyloid precursor protein (APP) expression, but APP processing/trafficking was markedly affected. In COS-7 cells, Abeta provokes retention of intracellular sAPPalpha (isAPPalpha). Intracellular holo-APP levels remain unchanged, and extracellular total sAPP i…

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