2012
DOI: 10.1186/1475-2875-11-156
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Abstract: BackgroundThe malaria burden remains a major public health concern, especially in sub-Saharan Africa. The complex biology of Plasmodium, the apicomplexan parasite responsible for this disease, challenges efforts to develop new strategies to control the disease. Proteolysis is a fundamental process in the metabolism of malaria parasites, but roles for proteases in generating vasoactive peptides have not previously been explored.ResultsIn the present work, it was demonstrated by mass spectrometry analysis that P… Show more

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Cited by 25 publications
(22 citation statements)
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“…Similarly, Plasmodium parasites including the deadly P. falciparum are able to internalize and process plasma kininogen and release vasoactive kinins (Lys‐BK, and des‐Arg 9 ‐BK) that may mediate hemodynamic alterations during acute malaria. Therefore, by altering the concentration of systemic or local kinins the plasmodium is able to induce vasodilatation and endothelial cell permeability to facilitate parasite survival . Although its functions outside the well known pathological conditions such as angioedema have been much overlooked, these examples show that BK is a significantly important pleiotropic molecule that is involved in diverse biological functions including cell proliferation and migration, angiogenesis, endothelial cell, leukocyte activation, and blood brain barrier permeability .…”
Section: Role Of Gc1qr In the Assembly Of The Kinin‐forming Cascadementioning
confidence: 99%
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“…Similarly, Plasmodium parasites including the deadly P. falciparum are able to internalize and process plasma kininogen and release vasoactive kinins (Lys‐BK, and des‐Arg 9 ‐BK) that may mediate hemodynamic alterations during acute malaria. Therefore, by altering the concentration of systemic or local kinins the plasmodium is able to induce vasodilatation and endothelial cell permeability to facilitate parasite survival . Although its functions outside the well known pathological conditions such as angioedema have been much overlooked, these examples show that BK is a significantly important pleiotropic molecule that is involved in diverse biological functions including cell proliferation and migration, angiogenesis, endothelial cell, leukocyte activation, and blood brain barrier permeability .…”
Section: Role Of Gc1qr In the Assembly Of The Kinin‐forming Cascadementioning
confidence: 99%
“…Therefore, by altering the concentration of systemic or local kinins the plasmodium is able to induce vasodilatation and endothelial cell permeability to facilitate parasite survival . Although its functions outside the well known pathological conditions such as angioedema have been much overlooked, these examples show that BK is a significantly important pleiotropic molecule that is involved in diverse biological functions including cell proliferation and migration, angiogenesis, endothelial cell, leukocyte activation, and blood brain barrier permeability . Bradykinin induces its activity via two G‐protein‐coupled receptors: bradykinin receptor 2 (B2R) and B1R While B2R is ubiquitously and constitutively expressed on many healthy cell types including ECs, B1R is expressed at low levels but is induced rapidly after tissue damage by IL‐1β or TNFα .…”
Section: Role Of Gc1qr In the Assembly Of The Kinin‐forming Cascadementioning
confidence: 99%
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“…Plasmodium proteases participate in essential events for parasite life, including the invasion of and egress from erythrocytes and hemoglobin degradation for the acquisition of amino acids [2][3][4]. Malaria parasite proteases, such as aspartic, cysteine, and serine proteases and metalloproteases, have been considered potential therapeutic targets [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…This was achieved by dual labelling with Fluo-3/AM which labels the heavy metal whose transport is studied and Hoechst which labels the parasite by binding to its DNA. Fluo-3/AM was scarcely used in the study of P. falciparum and in those cases it served for determination of Ca +2 metabolism [12-15]. Hoechst and derivatives is used more commonly and in all cases for the visualization of the parasite e.g.…”
Section: Introductionmentioning
confidence: 99%