1988
DOI: 10.1055/s-2007-1020090 View full text |Buy / Rent full text
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Abstract: Cellular edema and cardiac arrhythmias are often closely related to intracellular ionic alterations and, moreover, are an actual problem of clinical cardioplegia and ischemia of the heart. In order to investigate whether the clinically widely used cardioplegic solution of the St. Thomas' Hospital may predispose for these complications, membrane potential (EM), intracellular pH (pHi), and intracellular sodium and potassium activity (aiNa- and aiK) in sheep heart Purkinje fibres were directly measured by means o… Show more

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“…It has been suggested previously that inhibition of the Na ϩ -K ϩ pump by hypothermia might lead to cell swelling during cardioplegia in the absence of ischemia. 1,24 Each cycle of the Na ϩ -K ϩ pump extrudes 3 Na ϩ while taking up 2 K ϩ , a net efflux of osmotically active particles. As Na ϩ passively enters the cell, pump inhibition allows the accumulation of Na ϩ and thus water.…”
Section: Discussionmentioning
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“…It has been suggested previously that inhibition of the Na ϩ -K ϩ pump by hypothermia might lead to cell swelling during cardioplegia in the absence of ischemia. 1,24 Each cycle of the Na ϩ -K ϩ pump extrudes 3 Na ϩ while taking up 2 K ϩ , a net efflux of osmotically active particles. As Na ϩ passively enters the cell, pump inhibition allows the accumulation of Na ϩ and thus water.…”
Section: Discussionmentioning
“…On the other hand, depolarization to near -50 mV, as occurs during hyperkalemic arrest, increases Na ϩ influx and elevates the cytoplasmic [Na ϩ ]. 24 This may explain the more severe swelling of atrial cells in St. Thomas' Hospital solution and explain why low Cl -St. Thomas' Hospital solution failed to fully abolish their swelling. Alternatively, human atrial cells may be more permeant to methanesulfonate, the Clreplacement, than rabbit myocytes.…”
Section: Discussionmentioning