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Cited by 167 publications
(129 citation statements)
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References 30 publications
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“…Osteoblasts are highly specialized cells that are responsible for the development of bone, production of bone matrix proteins, maintenance of bone density, and formation of hydroxyapatite mineral (Marks and Hermey, 1996). Osteoblasts employ intracellular Ca 2+ as a second messenger modulating fluid shear stress or hormonal responses and also a cofactor for bone mineralization (Lieberherr et al, 1993;Heaney, 1996;Hung et al, 1996;Chen et al, 2000;Nesti et al, 2002). When sufficient amounts of calcium and phosphate are supplied, osteoblasts synthesize and secret a collagenous extracellular matrix that nucleates the formation of hydroxyapatite crystal, in response to diverse extracellular stimuli such as steroid hormones, growth factors, cytokines, biochemical signals and extracellular Ca 2+ concentration (Yamaguchi et al, 1998;McAllister and Frangos, 1999;De Jong et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
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“…Osteoblasts are highly specialized cells that are responsible for the development of bone, production of bone matrix proteins, maintenance of bone density, and formation of hydroxyapatite mineral (Marks and Hermey, 1996). Osteoblasts employ intracellular Ca 2+ as a second messenger modulating fluid shear stress or hormonal responses and also a cofactor for bone mineralization (Lieberherr et al, 1993;Heaney, 1996;Hung et al, 1996;Chen et al, 2000;Nesti et al, 2002). When sufficient amounts of calcium and phosphate are supplied, osteoblasts synthesize and secret a collagenous extracellular matrix that nucleates the formation of hydroxyapatite crystal, in response to diverse extracellular stimuli such as steroid hormones, growth factors, cytokines, biochemical signals and extracellular Ca 2+ concentration (Yamaguchi et al, 1998;McAllister and Frangos, 1999;De Jong et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…When sufficient amounts of calcium and phosphate are supplied, osteoblasts synthesize and secret a collagenous extracellular matrix that nucleates the formation of hydroxyapatite crystal, in response to diverse extracellular stimuli such as steroid hormones, growth factors, cytokines, biochemical signals and extracellular Ca 2+ concentration (Yamaguchi et al, 1998;McAllister and Frangos, 1999;De Jong et al, 2002). These stimuli elicit a transient rise of intracellular Ca 2+ concentration ( [Ca 2+ ] i ) which is triggered both by Ca 2+ release from intracellular Ca 2+ stores and Ca 2+ entry from extracellular fluid (Lieberherr et al, 1993;Hung et al, 1996;Chen et al, 2000;Nesti et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…77 As mentioned above, osteoblasts and osteocytes express a number of calcium-conducting channels, including Land T-type calcium channels and an unidentified mechanosensitive cation channel, 37,78,79 that are activated by fluid flow. Exposing cells to fluid flow in calciumfree media or pharmacological inhibition of these channels dampens the elevation of intracellular calcium in response to fluid flow.…”
Section: Mechanotransduction Pathwaysmentioning
confidence: 99%
“…Exposing cells to fluid flow in calciumfree media or pharmacological inhibition of these channels dampens the elevation of intracellular calcium in response to fluid flow. 21,77,80 Calcium signaling is similarly affected when intracellular calcium stores are emptied or phospholipase C activity is inhibited. 21,77,80 The increase in intracellular calcium concentration is reported to contribute to the enhanced expression of osteopontin, 21 c-fos, cyclooxygenase-2, 80 and transforming growth factor-b, 81 but there is little data on how this change in ion concentration results in altered gene expression.…”
Section: Mechanotransduction Pathwaysmentioning
confidence: 99%
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