Intra-pancreatic distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: a common short and long-term prognosis?

Guilbaud, Théophile; Girard, Édouard; Lemoine, Coralie; Schlienger, G.; Alao, Oyekashopefoluw; Risse, Olivier; Berdah, Stéphane; Chirica, Mircea; Moutardier, Vincent; Birnbaum, David

doi:10.1007/s13304-021-00981-0

Cited by 10 publications

(29 citation statements)

References 28 publications

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“…Moreover, in one report the progression-free survival was longer in minimally invasive group. Gilbaud et al 15 reported 3-year disease-free survival of 13.5%, with tumor size more than 2 cm was significant associated with worse outcome in multivariate analysis. Although the presence of many worse predictive factors associated with recurrence disease in our cases such as inadequate lymph node examination, large tumor size more than 2 cm 15 , lymphovascular invasion, perineural invasion, the patient remained disease-free after 35 months of follow-up.…”

Section: Discussionmentioning

confidence: 99%

A Safe Start Laparoscopic-assisted Pancreaticoduodenectomy in Songklanagarind Hospital, Thailand: Case Report

Thongkan¹,

Wiboonkhwan²,

Pitakteerabundit³

et al. 2021

J Health Sci Med Res

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Total laparoscopic pancreaticoduodenectomy (PD) is a highly complex procedure. Evidence suggests laparoscopic-assisted PD (LAPD) might be an important link in the process of transition from open PD to total laparoscopic PD. We present the first successful LAPD in a female patient with distal cholangiocarcinoma at Songklanagarind Hospital, Thailand in July 2018. The postoperative course was satisfactory without the clinical relevance of complications. No evidence of recurrence was found after 35 months of follow-up. The results ensured the feasibility and safety of LAPD in the initial phase; regarding both complications and oncological outcomes in a high-volume center for open PD.

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Section: Discussionmentioning

confidence: 99%

A Safe Start Laparoscopic-assisted Pancreaticoduodenectomy in Songklanagarind Hospital, Thailand: Case Report

Thongkan¹,

Wiboonkhwan²,

Pitakteerabundit³

et al. 2021

J Health Sci Med Res

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“…In this research, we also found that lymphatic metastasis was a prognostic factor for the OS of DCC patients (P<0.05). Although research has pointed out that lymphatic metastasis and harvested lymph nodes are prognostic factors for DCC (29), there are still few studies on the relationship between harvested lymph node number and the longterm survival of DCC. In our study, although the LPD group had more harvested lymph nodes in the original cohort (mean, 14.58 vs. 10.20, P=0.01), there was no statistical significance after PSM analysis (mean, 14.3 vs. 9.93, P=0.076).…”

Section: Discussionmentioning

confidence: 99%

Comparison of laparoscopic and open pancreaticoduodenectomy for the treatment of distal cholangiocarcinoma: A propensity score matching analysis

Zhu

Zu²,

Wu³

et al. 2022

Front. Oncol.

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BackgroundThere are few studies comparing the oncological outcomes of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) for distal cholangiocarcinoma (DCC). Our objective was to assess the short-term efficacy and long-term survival of LPD and OPD in patients with DCC.MethodsThe data of 124 DCC patients who underwent LPD or OPD at the Third Affiliated Hospital of Soochow University from May 2010 to May 2021 were retrospectively analyzed. Propensity score matching was performed to balance the two groups of baseline characteristics. After 1:1 matching, the overall survival (OS) of the two groups was compared by the Kaplan−Meier method. Univariate and multivariate Cox regression analyses were used to identify independent predictors of OS.ResultsThe original cohort consisted of 124 patients. Nineteen patients were excluded because of incomplete baseline or follow-up data, and the remaining 105 patients were divided into two cohorts (45 in the LPD group and 60 in the OPD group). The LPD group showed more favorable results in OS analysis (LPD vs. OPD, 56.4 [46.2-66.5] vs. 48.9 [36.4-61.4], months, P=0. 01). PSM analysis identified 30 pairs of patients, and differences between matching groups were still significant (LPD vs. OPD, 67.9[58.2-77.6] vs. 47.4[31.4-67.5], months, P=0.002). Moreover, the LPD group experienced less intraoperative bleeding (LPD vs. OPD, 292.67 vs. 519.17 mL, P=0.002). Univariate analysis showed that surgical modality (P=0.012), carbohydrate antigen 19-9 (P=0.043), carcinoembryonic antigen (P=0.003), neutrophil-to-lymphocyte ratio (P=0.012), blood transfusion (P=0.031), clinically relevant postoperative pancreatic fistula (P<0.001) and lymphatic metastasis (P=0.004) were predictors of OS. Multivariate Cox analysis demonstrated that carbohydrate antigen 19-9 (P=0.048), carcinoembryonic antigen (P=0.031) and lymphatic metastasis (P=0.023) were independent predictive factors of OS. However, adjuvant therapy had no significant effect on the OS of DCC patients after radical pancreaticoduodenectomy (P>0.05).ConclusionsFor DCC patients, LPD may be a more recommended procedure because of its advantages over OPD in terms of intraoperative bleeding and long-term survival.

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“…All these studies reported the overall survival (OS) or disease-free survival (DFS) via the Kaplan-Meier curves. Nine studies also compared the clinical-pathological features between DCCA and PDCA (1,(4)(5)(6)(7)(8)(12)(13)(14). Additionally, the study by Hester et al was based on the National Cancer Database (NCDB), and their patients were partly surgically treated and the others were undergoing palliative treatment (2004-2012) (7).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…There are no specific tumor biomarkers to date to distinguish them clearly (4). Moreover, accumulating evidence has suggested that despite their similar origin and surgical techniques, their clinical-pathological features and long-term prognosis were reported to be inconsistent to some extent (4)(5)(6)(7)(8)(9). For example, Andrianello et al revealed that lymphatic invasion and neural invasion were more frequently detected in patients with PDCA, and patients with DCCA had a significantly better prognosis (5).…”

Section: Introductionmentioning

confidence: 99%

“…For example, Andrianello et al revealed that lymphatic invasion and neural invasion were more frequently detected in patients with PDCA, and patients with DCCA had a significantly better prognosis (5). However, the study by Guilbaud et al revealed that both tumor types shared equal prognosis and oncological outcomes (8). The study introduced above either included a small sample size or just evaluated their differences from a few tumor-related features.…”

Section: Introductionmentioning

confidence: 99%

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The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Wang

et al. 2022

Front. Oncol.

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ObjectiveTo evaluate the consistencies and inconsistencies between distal cholangiocarcinoma (DCCA) and pancreatic ductal adenocarcinoma (PDCA) regarding their biological features and long-term prognosis.MethodsPubMed, the Cochrane Library, and EMBASE were searched to find comparative studies between DCCA and PDCA. RevMan5.3 and Stata 13.0 software were used for the statistical analyses.ResultsEleven studies with 4,698 patients with DCCA and 100,629 patients with PDCA were identified. Pooled results indicated that patients with DCCA had a significantly higher rate of preoperative jaundice (p = 0.0003). Lymphatic metastasis (p < 0.00001), vascular invasion (p < 0.0001), and peri-neural invasion (p = 0.005) were more frequently detected in patients with PDCA. After curative pancreaticoduodenectomy (PD), a significantly higher R0 rate (p < 0.0001) and significantly smaller tumor size (p < 0.00001) were detected in patients with DCCA. Patients with DCCA had a more favorable overall survival (OS) (p < 0.00001) and disease-free survival (DFS) (p = 0.005) than patients with PDCA. However, postoperative morbidities (p = 0.02), especially postoperative pancreatic fistula (POPF) (p < 0.00001), more frequently occurred in DCCA.ConclusionPatients with DCCA had more favorable tumor pathological features and long-term prognosis than patients with PDCA. An early diagnosis more frequently occurred in patients with DCCA. However, postoperative complications, especially POPF, were more frequently observed in patients with DCCA.

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Intra-pancreatic distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: a common short and long-term prognosis?

Cited by 10 publications

References 28 publications

A Safe Start Laparoscopic-assisted Pancreaticoduodenectomy in Songklanagarind Hospital, Thailand: Case Report

A Safe Start Laparoscopic-assisted Pancreaticoduodenectomy in Songklanagarind Hospital, Thailand: Case Report

Comparison of laparoscopic and open pancreaticoduodenectomy for the treatment of distal cholangiocarcinoma: A propensity score matching analysis

The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

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