Intra-Operative Use of 5-Fluorouracil in Pterygium Surgery:  A Comparative Study

Silva, Rodrigo Salustiano Correa e; Ávila, Marcos; Rassi, Alan Ricardo; Ximenes, Luciana; Silva, Diomario Salustiano da; Paula, Alcio Coutinho de

doi:10.3109/08820538.2012.730101

Cited by 11 publications

(2 citation statements)

References 13 publications

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“…2 . There were 10 trials that compared bevacizumab to placebo [ 23 – 27 , 31 – 35 ], 14 trials that compared MMC to placebo [ 16 , 36 – 48 ], 2 that compared 5-FU to placebo [ 49 , 50 ], 2 that compared β-RT to placebo [ 51 , 52 ], 2 that compared MMC to 5-FU [ 53 , 54 ], 1 that compared MMC to β-RT [ 11 ], 1 that compared bevacizumab to MMC [ 55 ], and 1 that compared bevacizumab with 5-FU [ 56 ]. One study compared either bevacizumab or MMC to placebo [ 57 ] (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis

et al. 2017

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BackgroundAnti-fibrotic, anti-VEGF (vascular endothelial growth factor) medications, or radiotherapy, as adjuvant for pterygium surgical procedure, has been suggested for reducing recurrence, but difficulties may be experienced in deciding which treatment to use. The purpose of this study was to compare the efficacies of these different adjuvants for preventing recurrence following pterygium surgery.MethodsWe conducted a systematic review to identify randomized controlled trials of patients with primary or recurrent pterygium who received anti-fibrotic, anti-VEGF medication, or radiotherapy as adjuvants in combination with surgical procedure. The surgical procedure contained bare sclera technique or petrygium excision combination with tissue grafting. The primary outcome of this study was recurrence. Direct-comparison and Bayesian network meta-analyses were performed to assess direct and indirect evidence of efficacy.ResultsWe obtained data from 34 randomized controlled trials, representing a total of 2483 patients. Adjuvants included bevacizumab, 5-FU (5-fluorouracil), MMC (mitomycin C), and β-RT (beta-radiotherapy). Compared with placebo, we found distinguishable improvement in recurrence with bevacizumab (odds ratio [OR] 0.38, 95% confidence interval [CI] 0.18–0.80), MMC (0.12, 95% CI 0.06–0.21), and β-RT (0.17, 95% CI 0.04–0.69), but not with 5-FU (0.41, 95% CI 0.12–1.39). MMC significantly reduced recurrence when compared to bevacizumab (0.31, 95% CI 0.13–0.77) and 5-FU (0.28, 95% CI 0.08–0.99). The probability of having the most recurrences after excision was lowest for MMC, followed by bevacizumab and β-RT. Similar results were found in subgroup analyses, including for primary pterygium, and the patients receiving bare sclera technique or conjunctival autograft.ConclusionsAdjuvants such as MMC, bevacizumab, and β-RT could effectively prevent recurrence following pterygium excision. However, their efficacy and acceptability require further clarification in future randomized controlled trials.Electronic supplementary materialThe online version of this article (10.1186/s12886-017-0601-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis

et al. 2017

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“…5-FUhas long been utilized in pterygium as an adjuvant to prevent recurrence. 18,19 However, use of 5FU as sole therapy to halt progression and recurrence of pterygium is relatively recent. Said et al reported that intralesional 5FU could halt pterygium progression; avoiding need for surgery.…”

Section: Discussionmentioning

confidence: 99%

Sub-conjunctival injection of 5 Fluorouracilversus Bevacizumab in Treatment of Primary Pterygium

Shagufta Parveen,

Saquib Naeem,

Waqar Muzaffar

et al. 2023

pak J Ophthalmol

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Purpose: To compare effectiveness and safety of 5 Fluorouracil versus Bevacizumab as sole therapy in the treatment of primary pterygium. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital Lahore, from January 2022 to January 2023. Methods: A total of 64 patients were included and divided into 2 groups of 32 patients each. Group A patients received monthlyinjection of 0.1ml, Fluorouracil(5FU) for 3 months while 3 injections of 0.1ml Bevacizumab were administered in group B. Primary outcome measure was effectiveness (defined as improvement in Pterygiumgrade), at 4 weeks following the administration of last injection. Patients were examined for pterygium grading as well as any side effects of injections on each follow up visit. Data analysis was done bySPSS, Version 23.0. Results: Mean age of patients in group A was of 33.53±11.3 yearsversus 30.97±12.6 years in group B with a range of 15–55 years. There were 45 (70.3%) males and 19 (29.7%) females. Improvement was seen in 21 patients (65.6%) in group A, as compared to only 2 (6.3%) in group B. There was a significant difference in pterygium improvement between the two groups (p<0.001). Conclusion: 5 Fluorouracil is more effective than Bevacizumab as sole therapy in treatment of primary pterygium but equally safe in terms of side effects.

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Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial

Akbari,

Moghadam,

Leili

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Intra-Operative Use of 5-Fluorouracil in Pterygium Surgery: A Comparative Study

Abstract: This study suggests that antifibroproliferative therapy with intraoperative sponge 5-FLU is effective and safe. Its use may be a useful adjunct in primary pterygium surgery.

Cited by 11 publications

References 13 publications

Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis

Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis

Sub-conjunctival injection of 5 Fluorouracilversus Bevacizumab in Treatment of Primary Pterygium

Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial

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