JAMA
 2008
DOI: 10.1001/jama.299.24.2877
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Intra-individual Change Over Time in DNA Methylation With Familial Clustering

Hans T. Björnsson
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Cited by 708 publications

(568 citation statements)
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“…Our results indicate that genetic background as well as tissue environment can influence global DNA methyation patterns. This conclusion is consistent with previous studies that showed genetic background affected global chromatin modifications [22] , [23] , [24] , [25] , [32] .…”
Section: Resultssupporting
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our results indicate that genetic background as well as tissue environment can influence global DNA methyation patterns. This conclusion is consistent with previous studies that showed genetic background affected global chromatin modifications [22] , [23] , [24] , [25] , [32] .…”
Section: Resultssupporting
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, the level can still be altered, potentially by environmental risk factors for RA, such as smoking. This is consistent with a previous observation of familial clustering of changes in global DNA methylation over time [25]. …”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our study showed LINE-1 was significantly hypermethylated in T2DM patients, lower LINE-1 DNA methylation levels were associated with a reduced risk of T2DM. Different from other studies, no correlation was found between age, gender and LINE-1 methylation [ 33 , 34 ]. Additionally, DNA methylation changes are indicated to involve in the development of some complex diseases and might be useful in predicting the risk of T2DM and CVD.…”
Section: Discussioncontrasting
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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