Intra-Incisional Prophylactic Antibiotics for Dermatologic Surgery

Clindamycin for Intraincisional Antibiotic Prophylaxis in Dermatologic Surgery

“…Ciprofloxacin was also considered, but despite adequate activity against S aureus, it has less activity against Streptococcus species. The potential benefits of intraincisional antibiotic prophylaxis 2 include immediate delivery to the site where it is needed, ease of use, enhanced compliance, and low cost compared with other routes of delivery. There are also theoretically decreased potentials for resistance, drug interactions, intolerance, and bacterial or fungal overgrowth because miniscule quantities are delivered into a localized site.…”

“…2 Unfortunately, there are many patients with a potential or documented allergy to penicillin or the penicillin class of antibiotics. For these patients, use of nafcillin is contraindicated, and an alternative antibiotic for intraincisional prophylaxis would be desirable.…”

Prospective evaluation of surgical site infection rate among patients with Mohs micrographic surgery without the use of prophylactic antibiotics

“…Other surgeons opt to place patients undergoing MMS with certain types of closures or in certain locations on antibiotic prophylaxis routinely without solid evidence to support surgical site infection such practices. 1,2,4,5,[25][26][27][28] These practices may increase patient exposure to potential adverse events and increase antibiotic resistance.…”

Aesthetic and Functional Efficacy of Subcuticular Running Epidermal Closures of the Trunk and Extremity

“…With the exception of trials examiningtheutilityoftissueadhesives, [2][3][4] there are exceedingly few clinical trials specifically comparing the functional and aesthetic outcomes associated with different excision closure techniques. In general, the extant literature examining outcomes after elliptical excisionsisfocusedonpretreatmentprophylaxis of adverse events 5 or posttreatment scar modification, by laser 6 and other means, 7 rather than on the initial choice of closure.…”