Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis

Haupenthal, Daniela Pacheco dos Santos; Resmini, M.B.; Silva, Leandro Almeida Da; Colares, Mateus Cardoso; Casagrande, Laura de Roch; Venturini, Ligia Milanez; Andrade, Thiago Antônio Moretti de; Bomfim, Fernando Russo Costa do; Thirupathi, Anand; Feuser, Paulo Emílio; Dal‐Pizzol, Felipe

doi:10.2174/1389450124666221212090319

Cited by 2 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biomolecules can have their environmental friendliness and utility multiplied through genetic engineering, allowing for modification. Biodegradable polymers and bio-based fuels are part of this category [17].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical perspectives on bio-molecular environmental regulation: Long-term strategies

2024

mcb

View full text Add to dashboard Cite

Environmentally conscious practices can be encouraged in many organisations through this study, which has the potential to change our understanding of bio-molecular interactions in natural systems. There is an immediate need for innovative approaches to environmentally responsible bio-molecule management due to the critical nature of environmental problems such as pollution, climate change, and resource depletion. Using state-of-the-art computational biomechanics and organic sciences, this study presents an approach to environmental governance known as Integrative Biomechanical Modelling for Environmental Governance Technique (IBM-EGT). A combination of environmental parameterization, advanced biomechanical modelling, and excellent data sets allows the IBM-EGT method to describe the behaviour of biomolecules in a wide variety of natural settings. By factoring in environmental variables like temperature, pH, and pollutant concentrations, IBM-EGT provides a comprehensive picture of bio-molecular dynamics in response to environmental stimuli. Biomaterials, bioremediation, pharmaceuticals, and even agriculture are just a few of the many potential sectors that can profit from IBM-EGT. Agricultural operations can be optimised, green medicines can be introduced, sustainable biomaterials can be developed, and diseased regions can be cleaned up with its help. Because it enables the prediction of bio-molecular interactions and behaviour in complex environmental contexts, simulation analysis is a fundamental topic of IBM-EGT. In an effort to find the best ways to conduct activities while reducing negative environmental impacts and increasing positive ones, IBM-EGT does scenario analysis based on simulations. The studies mentioned here help keep the environment and people healthy by elucidating the nature of the connection between Bio-Molecules and their herbal environment. Furthermore, it enables the development of plans for the distant future.

show abstract

Section: Introductionmentioning

confidence: 99%

Biomechanical perspectives on bio-molecular environmental regulation: Long-term strategies

2024

mcb

View full text Add to dashboard Cite

show abstract

Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of preclinical evidence by the ESSKA Orthobiologic Initiative

Bensa,

Salerno,

Boffa

et al. 2024

Knee surg. sports traumatol. arthrosc.

View full text Add to dashboard Cite

PurposeAim of this systematic review of preclinical evidence was to determine the effects of intra‐articular corticosteroid (CS) injections in joints affected by osteoarthritis (OA).MethodsA systematic review was performed on animal studies evaluating intra‐articular CS injections for OA joints. The search was performed on PubMed, Cochrane, and Web of Science databases. A synthesis of the results was performed investigating CS effects by evaluating studies comparing CS with control groups. Morphological, histological, immunohistochemistry evaluations, clinical outcomes, biomarkers and imaging results were evaluated. The risk of bias was assessed according to the Systematic Review Centre for Laboratory Animal Experimentation's tool.ResultsThirty‐two articles analysing CS effects in OA animal models were included (1079 joints), 18 studies on small and 14 on large animals. CS injections showed overall positive effects in at least one of the outcomes in 68% of the studies, while 16% reported a deleterious effect. CS improved cartilage and synovial outcomes in 68% and 60% of the studies, but detrimental effects were documented in 11% and 20% of the studies, respectively. Clinical parameters evaluated in terms of pain, lameness or joint swelling improved in 63% of the studies but deteriorated in 13%. Evidence is limited on imaging and biomarkers results, as well as on the best CS type, dose, formulation and injection protocol. The risk of bias assessment revealed a 28% low and an 18% high risk of bias.ConclusionIntra‐articular CS injections induced a wide range of results on OA joints in experimental animal models, from disease‐modifying and positive effects on pain and joint function at short‐term evaluation to the lack of benefit or even negative effects. This underlines the need to identify more specific indications and treatment modalities to avoid possible detrimental effects while maximising the anti‐inflammatory properties and the benefits of intra‐articular CS in OA joints.Level of EvidenceLevel II.

show abstract

Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis

Cited by 2 publications

References 55 publications

Biomechanical perspectives on bio-molecular environmental regulation: Long-term strategies

Biomechanical perspectives on bio-molecular environmental regulation: Long-term strategies

Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of preclinical evidence by the ESSKA Orthobiologic Initiative

Contact Info

Product

Resources

About