Intra-Articular Autologous Platelet Concentrate (APC) in the Treatment of Induced Knee Osteoarthritis (OA) in Rabbits — An Arthroscopic Evaluation

Abstract

The treatment of osteoarthritis is a constant challenge in veterinary and human medicine. It is a disabling disease of widespread occurrence, whose primary purpose of treatment has been the relief of pain and improvement or maintenance of joint function. New therapeutic alternatives are continuously researched around the world. Among the alternatives is the use of autologous platelet concentrate (APC) or platelet rich plasma (PRP) intra-articular. CAP may have an important role in modifying therapy of osteoarthritis. It is easy to use and relatively low cost, which has led to research interest and to a wide clinical application. Clinical use has shown positive results, but standardized scientific studies and continued evaluation of the treatment are lacking. Many questions remain unanswered. Arthroscopy is a diagnostic and therapeutic method that can help to understand the action of this therapy. Experimental studies show marked reduction of synovitis, which explains the improvement observed in clinical cases.