Intoxicação por Baccharis megapotamica var. weiriiem ovinos

Pedroso, Pedro Miguel Ocampos; Bandarra, Paulo Mota; Feltrin, Cristiano; Gomes, Danilo Carloto; Watanabe, Tatiana T. N; Ferreira, Hugo Henrique; Driemeier, David

doi:10.1590/s0100-736x2010000500005

Cited by 10 publications

(20 citation statements)

References 5 publications

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“…26 Baccharis artemisioides causes disease in cattle in a restricted zone of Argentina northwest of Buenos Aires and southeast of Cordoba. 22 Nearly 120 species of Baccharis have been recorded in Brazil; of those, only Baccharis coridifolia 4,27 and Baccharis megapotamica 7,19,28 have been proven to be toxic to livestock. Both B. megapotamica and B. coridifolia are found in southern Brazil, but they occupy different habitats; B. megapotamica is found in marshy areas 28 whereas B. coridifolia grows in pastureland.…”

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Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

et al. 2011

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Abstract. An outbreak of an acute disease in buffalo (Bubalus bubalis) caused by the ingestion of Baccharis megapotamica var. weirii occurred in the southern region of Brazil. Ten out of 50 buffalo died 24-48 hr after being introduced into a pasture containing abundant amounts of the plant. Factors influencing the ingestion of the plant and consequent toxicosis included hunger, stress caused by shipment, and unfamiliarity with the plant. Clinical signs included serous ocular discharge, incoordination, mild bloat, and muscle trembling. One buffalo was necropsied. Gross findings included dehydration, abundant liquid in the rumen, reddening of the mucosa of forestomachs, abomasum, and intestine, and edema of the wall of the rumen. The main histologic lesions were superficial to full thickness degeneration and necrosis of the stratified epithelium lining the forestomachs, necrosis of the intestinal mucosa, and widespread lymphoid necrosis. A calf (Bos taurus) was fed a single dose of 5 g/kg/body weight of B. megapotamica var. weirii harvested from the same site where the buffalo died. Twenty hours after the administration of the plant this calf died with clinical signs and lesions similar to those observed in the naturally poisoned buffalo.

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Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

et al. 2011

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“…weirii (Baker) G.M.Barroso (Asteraceae) é considerada uma planta tóxica causadora de edema de submucosa no rúmen, tumefação, vacuolização e necrose de mucosas, levando a morte de ovinos (Pedroso et al, 2010).…”

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Espécies bioativas em áreas úmidas do Planalto Catarinense

Silva

Bortoluzzi

Gomes

et al. 2013

Rev. bras. plantas med.

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O objetivo deste trabalho foi levantar e identificar as espécies vegetais que ocorrem em áreas úmidas (banhados) do Planalto Catarinense e associá-las aos seus respectivos potenciais bioativos, validados em testes laboratoriais ou relatados em estudos etnobotânicos. O estudo foi realizado em 12 áreas de banhados localizadas em fazendas com reflorestamentos comerciais de espécies exóticas de propriedade da Empresa Klabin S.A. A amostragem da vegetação foi realizada por meio de transecção no sentido transversal na maior largura dos banhados e na área de transição destes com a área mais drenada (em faixa limitada de três metros), onde foram coletados os espécimes férteis a cada metro da transecção. Após a identificação das espécies foi realizada uma revisão bibliográfica sobre o potencial bioativo das mesmas junto à bases de dados científicos utilizando-se os trabalhos que atestam o potencial e também os trabalhos que valorizam o conhecimento de populações locais. Nas áreas amostradas foram identificadas 235 espécies classificadas em 40 famílias botânicas. Destas, 28 espécies, classificadas em 11 famílias, possuem potencial bioativo. Do total de espécies identificadas, 18 apresentaram potencial validado cientificamente e 10 são citadas quanto ao seu potencial em trabalhos de etnobotânica. Ainda é pouco conhecida a diversidade de banhados no Planalto Catarinense sendo necessário mais estudo para o conhecimento da flora local. O estudo mostrou um grande número de espécies com potencial validado e que poderiam ser utilizadas pela população, enquanto outras que merecem pesquisas complementares.

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“…weirii poisoning by in buffalo (Oliveira-Filho et al 2011) in cattle (Driemeier et al 2000) and sheep (Pedroso et al 2010) and the experimental intoxication in cattle with this plant species (Tokarnia et al 1992). The lesions are also similar to those produced by B. coridifolia in cattle (Tokarnia & Döbereiner 1975, Barros 1998, Rissi et al 2005) and sheep (Rozza et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…weirii have been reported in cattle (Driemeier et al 2000) sheep (Pedroso et al 2010) and buffaloes (Oliveira-Filho et al 2011). There are also some anecdotal accounts of spontaneous toxicosis by B. megapotamica var.…”

Section: Introductionmentioning

confidence: 92%

“…Nearly 120 species of Baccharis have been recorded in Brazil; of those, only B. coridifolia (Tokarnia & Döbereiner 1975, Barros 1998 and B. Megapotamica (Tokarnia et al 1992, Driemeier et al 2000, Pedroso et al 2010 have been proven to be toxic to livestock. Both B. megapotamica and B. coridifolia are found in southern Brazil, but they occupy different habitats; B. megapotamica is found in marshy areas (Tokarnia et al 1992) whereas B. coridifolia grows in pastureland (Barros 1998).…”

Section: Introductionmentioning

confidence: 99%

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Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

et al. 2012

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Pesq. Vet. Bras. 32(5):383-390, maio 2012 383 RESUMO.-[Intoxicação experimental por Baccharis megapotamica var. weirii em búfalos.] As partes aéreas verdes de Baccharis megapotamica var. weirii foram administradas oralmente a cinco búfalos da raça Murrah de 6-8 meses de idade nas doses de 1, 3, 4, 5 e 10g/kg de peso corporal (pc) (~1-10mg de tricotecenos macrocíclicos/kg/ pc). A planta usada no experimento foi colhida numa fazenda onde um surto recente de intoxicação espontânea por essa planta havia ocorrido. Nos búfalos deste experimento, os sinais clínicos apareceram 4-20 horas e 4 búfalos morreram 18-49 horas após a ingestão da planta. Os sinais clíni-cos consistiram de apatia, anorexia, diarreia aquosa, febre, cólica, salivação, tremores musculares, inquietação, respiração laboriosa, atonia ruminal e desidratação. Five male 6-8 month-old Murrah buffalo calves were orally dosed with the fresh aerial parts of Baccharis megapotamica var. weirii at doses of 1, 3, 4, 5 and 10g/kg body weight (bw) (~1-10mg macrocyclic trichothecenes/kg/bw). The B. megapotamica used for the experiment was harvested on a farm where a recent spontaneous outbreak of poisoning caused by such plant had occurred. Clinical signs appeared 4-20 hours and 4 buffaloes died 18-49 hours after the ingestion of the plant. Clinical signs were apathy, anorexia, and watery diarrhea, fever, colic, drooling, muscle tremors, restlessness, laborious breathing and ruminal atony, and dehydration. The most consistent gross ϐindings were restricted to the gastrointestinal (GI) tract consisted of varying degrees of edema and reddening of the mucosa of the forestomach. Histopathological ϐindings consisted of varying degrees of necrosis of the epithelial lining of the forestomach and of lymphocytes within lymphoid organs and aggregates. Fibrin thrombi were consistently found in sub-mucosal vessels of the forestomach and in the lumen of hepatic sinusoids. It is suggested that dehydration, septicemia and disseminated intravascular coagulation participate in the pathogenesis of the intoxication and play a role as a cause of death. A subsample of B. megapotamica var. weirii was frozen-dried and ground and analyzed using UHPLC (Ultra High Performance Liquid Chromatography) with high resolution Time of Flight mass spectrometry and tandem mass spectrometry, it was shown that the plant material contained at least 51 different macrocyclic trichothecenes at a total level of 1.1-1.2mg/g. About 15-20% of the total trichothecenes contents was found to be monosaccharide conjugates, with two thirds of these being glucose conjugates and one third constituted by six aldopentose conjugates (probably xylose), which has never been reported in the literature.

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Intoxicação por Baccharis megapotamica var. weiriiem ovinos

Cited by 10 publications

References 5 publications

Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

Baccharis megapotamica var. weirii poisoning in water buffalo (Bubalus bubalis)

Espécies bioativas em áreas úmidas do Planalto Catarinense

Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

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