Intoxicação natural por Senecio brasiliensis em equinos

Panziera, Welden; Bianchi, Ronaldo Michel; Mazaro, Renata Dalcol; Giaretta, Paula R.; Silva, Gabriele B.; Silva, Diego R.P.; Fighera, Rafael A.

doi:10.1590/s0100-736x2017000400003

Cited by 7 publications

(12 citation statements)

References 18 publications

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“…The macroscopic alterations found in the liver of the three equines were also compatible with what the literature describes for these species, such as lobular pattern accentuation, firm consistency at cut and the presence of hemorrhagic areas [1,7,10]. As for the microscopic analysis of cases of poisoning by Senecio brasiliensis in horses, the alterations are mainly found in the liver and in the central nervous system [1,10,11].…”

Section: Discussionsupporting

confidence: 87%

“…As in the cases of the present study, it can be evidenced in the liver hepatic architecture loss, megalocytosis, fibrosis, bile duct hyperplasia, intrahepatic and intracanalicular cholestasis, and hepatocellular degeneration and necrosis [1,7,10,11]. While in the brain spongiosis in gray and white matter, degeneration and neuronal necrosis and presence of Alzheimer type II astrocytes can be noticed [1,7,14].…”

Section: Discussionsupporting

confidence: 63%

“…Thus, the diagnosis of poisoning was obtained through the association of the epidemiological study, which indicated the presence of Senecio brasiliensis at the grazing sites where the animals were allocated, the signs observed during clinical care, and the findings of necropsy and histopathology. It is important to point out that the histological lesions were fundamental to establish the diagnosis, which are observed both in cases of natural and experimental poisoning in horses [1,4,7,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…in cattle are more frequent than in equines, although the two species are considered the most susceptible [14]. There are few reports of cases of natural intoxication [1] and experimental [10] in horses in Brazil, where the disease usually presents a chronic clinical course, but cases of acute intoxication may also occur [7,14].…”

Section: Introductionmentioning

confidence: 99%

“…Intoxicated animals usually present with apathy, anorexia, dysphagia, emaciation, subcutaneous edema, icterus and neurological disorders [1,10,11,14], and post-mortem examination shows lesions in the liver and central nervous system including fibrosis, megalocytosis, spongiosis and appearance of Alzheimer's type II astrocytes [7,14]. To date, this intoxication has not been diagnosed in the area covered by the Animal Pathology Laboratory of the University of Passo Fundo.…”

Section: Introductionmentioning

confidence: 99%

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Poisoning by Senecio brasiliensis in Horses in Northern Rio Grande do Sul

Dau

Machado

Santos

et al. 2019

Acta Scientiae. Vet.

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Background:In various regions of Brazil, horses and cattle are considered the most susceptible animals to plant poisoning. The plants of the genus Senecio are the most important in Rio Grande do Sul because they have the active principle known as the pyrrolizidine alkaloid. Its diagnosis is made through epidemiology, clinical signs and histopathological analysis, either of the tissues obtained by biopsy or necropsy. The objective of this study was to report and characterize the epidemiological, clinical and anatomopathological findings of three cases of natural poisoning by Senecio brasiliensis in horses assisted at the Hospital Veterinário (HV) of the Universidade de Passo Fundo (UPF). Cases: Three traction horses, two males and one female, were admitted at the HV-UPF for clinical care. The animals were presenting anorexia, weight loss, dysmetria, proprioceptive deficit and signs suggestive of colic. The epidemiological study revealed that the sites where these animals were located were infested by Senecio brasiliensis. The support therapy used for equine colic in all three cases was unsuccessful. One of the animals died and the other two were euthanized, all three of them being reffered for necropsy. The post-mortem findings were mainly found in the liver, which showed accentuation of the lobular pattern and the appearance of nutmeg. During necropsy, fragments of organs from thoracic and abdominal cavities and central nervous system were collected and fixed in 10% buffered formalin. Subsequently, the samples were processed chemically, submitted to cuts of five micrometers of thickness and stained with hematoxylin and eosin for microscopic analysis. Microscopically, the liver of all three horses presented megalocytosis, fibrosis and bile ducts hyperplasia. In the central nervous system, spongiosis and the presence of Alzheimer type II astrocytes were observed. Thus, through the association of information, the diagnosis of poisoning by Senecio brasiliensis was achieved. Discussion: The diagnosis of natural poisoning by Senecio brasiliensis was obtained through the epidemiological survey that showed S. brasiliensis in pastures where all three horses were allocated. Cases of intoxication by S. brasieliensis in cattle are more frequent than in equines, although both species are considered the most susceptible. In horses, the main clinical manifestations observed include neurological disorders, apathy, anorexia, dysphagia, weight loss, subcutaneous edema and icterus. The clinical signs presented by the equines suggested initial signs of colic syndrome, although anorexia, weight loss, dysmetria and proprioceptive deficit are commonly observed in pyrrolizidine alkaloid poisoning in the liver, both in cattle and horses. The pyrrolizidine alkaloids present in the genus Senecio that become toxic when biotransformed in the liver into a pyrrholic form highly reactive that inhibits cell mitosis and leads to the onset of megalocytosis, cell death and liver fibrosis. The necropsy findings and histopathology were characteristic...

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