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Cited by 3 publications
(4 citation statements)
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“…Actually, the risk of intestinal resection could be influenced by several factors other than medication, such as improved access to diagnostic procedures, improved awareness of the disease, early CD diagnosis before development of bowel damage, and strict monitoring strategies. 50 , 51 Additionally, the clinical decision-making on intestinal resection for patients with CD can be influenced by multiple factors, including the preferences of patients and physicians, medical costs, and cultural differences. Hence, subsequent well-designed studies controlling multiple potential confounders and applying a consistent treatment algorithm for CD patients are required to prove the causal relationship between various drugs and intestinal resection.…”
Section: Discussionmentioning
confidence: 99%
“…Actually, the risk of intestinal resection could be influenced by several factors other than medication, such as improved access to diagnostic procedures, improved awareness of the disease, early CD diagnosis before development of bowel damage, and strict monitoring strategies. 50 , 51 Additionally, the clinical decision-making on intestinal resection for patients with CD can be influenced by multiple factors, including the preferences of patients and physicians, medical costs, and cultural differences. Hence, subsequent well-designed studies controlling multiple potential confounders and applying a consistent treatment algorithm for CD patients are required to prove the causal relationship between various drugs and intestinal resection.…”
Section: Discussionmentioning
confidence: 99%
“…Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, a chronic immunologically mediated disease with various risk factors, has traditionally been found in North America and Western Europe but, in recent years, is increasing globally 1 . Clinical outcomes for IBD have improved, as evidenced by decreased intestinal resection rates in Crohn's disease 2 . However, IBD is still regarded as an incurable chronic and debilitating intestinal disease with limited available therapies, which causes an increased risk for colon cancer, depression, and morbidity 3 .…”
Section: Introductionmentioning
confidence: 99%
“…1 Clinical outcomes for IBD have improved, as evidenced by decreased intestinal resection rates in Crohn's disease. 2 However, IBD is still regarded as an incurable chronic and debilitating intestinal disease with limited available therapies, which causes an increased risk for colon cancer, depression, and morbidity. 3 Developing novel anti-IBD therapies is needed to improve the life quality of IBD patients.…”
Section: Introductionmentioning
confidence: 99%
“… 2 Anti‐tumor necrosis factor (TNF) α therapy has resulted in a paradigm shift in the management of CD, improving outcomes and reducing intestinal resection rates. 3 , 4 On the other hand, loss of responsiveness after anti‐TNFα agent treatment has been reported. 5 Moreover, a risk of increased susceptibility to infections and a possible propensity for malignancy have limited the long‐term use of these drugs.…”
Section: Introductionmentioning
confidence: 99%