Intestinal Preconditioning Ameliorates Ischemia-Reperfusion Induced Acute Lung Injury in Rats: An Experimental Study

Avgerinos, Efthimios D.; Kostopanagiotou, Georgia; Costopanagiotou, Constantinos; Kopanakis, Nikolaos; Andreadou, Ioanna; Lekka, Marilena E.; Nakos, George; Smyrniotis, Vasilios

doi:10.1016/j.jss.2008.12.017

Cited by 20 publications

(14 citation statements)

References 40 publications

(52 reference statements)

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“…Moreover, IP protects against intestinal IR injury via the mast cell degranulation-mediated release of mast cell carboxypeptidase A [1] . Furthermore, IP attenuates intestinal IR injury via actions in several signaling pathways, including suppression of heme oxygenase [16] and modulation of the arachidonic acid cascade [17] . Our previous study showed that intestinal IP attenuates the capacity of antioxygen-free radicals, inhibits the release of proinflammatory cytokines, and alleviates apoptosis in IR-caused lung injury in rats [4] .…”

Section: Discussionmentioning

confidence: 99%

Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats

Wang

et al. 2015

WJG

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Section: Discussionmentioning

confidence: 99%

Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats

Wang

et al. 2015

WJG

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“…The arachidonic acid cascade is an important factor in the ischemia reperfusion injury, and the ischemic preconditioning partly modulates this pathway 20 .…”

Section: Discussionmentioning

confidence: 99%

Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury

Neto

Koike

Abrahão³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To assess ischemic preconditioning (IPC) effects in pulmonary lesion in intestinal and hepatic ischemia-reperfusion (IR) injury models using diabetic rats.METHODS: Diabetes (DM) was induced in 28 male Wistar rats by alloxan (42 mg/kg, IV). After 28 days, severe DM rats were submitted to intestinal or hepatic IR injury with or without IPC. Intestinal IR (30 min of mesenteric artery occlusion and 30 min of reperfusion; n=6) and IPC groups (10 min ischemia, 10 min reperfusion, followed by intestinal IR; n=6), and Hepatic IR (30 min of hepatic pedicle occlusion and 30 min of reperfusion; n=5) and IPC groups (10 min ischemia, 10 min reperfusion, followed by hepatic IR; n=5), were compared to DM rats group (n=6). Plasmatic lactate, glycemia were measured before and after IR injury. Histomorphology of lung was performed counting inflammatory cells. Data was expressed in mean± SE. P<0.05. RESULTS:Glycemia and lactate were similar among groups. IPC did not interfere in these parameters. On histological evaluation, IR increased inflammatory cells infiltration in pulmonary parenchyma compared to control in both IR injury models. IPC attenuated inflammatory infiltration in lungs. CONCLUSION:Ischemic preconditioning protects against remote ischemia-reperfusion injury in lung on intestinal or hepatic ischemiareperfusion model with acute diabetes.Key words: Ischemia. Reperfusion. Ischemic Preconditioning. Lung. Diabetes Mellitus. Rats. Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury

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“…I/R involves the release of a large number of inflammatory mediators, including cytokines, arachidonic acid metabolites and NO [5]. Activated neutrophils, ROS, complement activation and endotoxemia also play a critical role in the development of lung injury [6]. The neutrophils and their enzymatic products are sequestrated in lung tissue, which causes increased microvascular permeability, perivascular and interstitial edema, and ultimately leads to pulmonary edema [5].…”

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confidence: 99%

Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats

Barut¹,

Özaçmak²,

TURAN³

et al. 2016

CIM

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Purpose: Multiple organ failure, including acute lung injury, is a common complication of intestinal ischemia and reperfusion (I/R) injury and contributes to its high mortality rate. Activated polymorphonuclear neutrophils and reactive oxygen species contribute to the lung injury caused by intestinal I/R. Mineralokortikoid receptor antagonist spironolactone has a protective effect against I/R injury in animal models of retina, kidney, heart, and brain. The aim of the present study is to investigate the effect of aldosteron receptor blocker spironolactone on lung injury induced by intestinal I/R.Methods: Wistar albino rats were divided into four groups: (1) sham control; (2) intestinal I/R (30 min of ischemia by superior mesenteric artery occlusion followed by 3 h of reperfusion); (3) spironolactone pretreatment (20 mg/kg) + I/R; and, (4) spironolactone pretreatment without I/R. Spironolactone was given orally 3 days prior to intestinal I/R. A marker for lipid peroxidation (malondialdehyde; MDA), an indicator or oxidation state (reduced glutathione; GSH), an index of polymorphonuclear neutrophil sequestration (myeloperoxidase; MPO), inducible nitric oxide synthase (iNOS) immunoreactivity, and the histopathology of the lung tissue were analyzed.Results: Spironolactone pretreatment markedly reduced intestinal I/R-induced lung injury as indicated by histology and MDA and MPO levels. Moreover, the pretreatment decreased the iNOS immunoreactivity. Conclusion:The present study strongly suggests that spironolactone pretreatment decreased neutrophil infiltration, iNOS induction, oxidative stress, and histopathological injury in an experimental model of intestinal I/R induced-lung injury of rats.

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Intestinal Preconditioning Ameliorates Ischemia-Reperfusion Induced Acute Lung Injury in Rats: An Experimental Study

Cited by 20 publications

References 40 publications

Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats

Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats

Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury

Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats

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