Intestinal microbiota and its relationship with diabetes and obesity

Pokrzywnicka, Patrycja; Gumprecht, Janusz

doi:10.5603/dk.2016.0029

Cited by 12 publications

(18 citation statements)

References 53 publications

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“…Adults contain about 100 billion bacteria only in the intestines, and the microbiome occupies approximately 90% of the cells in the human body [28]. The human genome consists of about 21,000 genes encoding proteins [29], and microbiota can contain about three million genes [22,27,30], which is 100 times greater than the human genome [24,31,32]. It is believed that the human microbiota is as unique as the fingerprints of a person [27].…”

Section: Human Microbiotamentioning

confidence: 99%

“…At birth, children are in contact with the bacterial flora of the vagina and the mother's anus [41]. Despite this, the microbiota of the child's intestines is finally formed after birth [3,8,27,32,35].…”

Section: Human Microbiotamentioning

confidence: 99%

“…There is a significant reduction in the number of Bacteroides and Bifidobacterium; thus, Clostridium, Eubacterium, and Fusobacterium begin to dominate. The result is an increase in the pH of the intestinal contents to about 7.0-7.5, which may be a cause of diseases of the digestive system in the elderly people [32,40].…”

Section: Human Microbiotamentioning

confidence: 99%

“…The microbiota controls numerous metabolic functions, many of which have still not been recognized [34,50]. Normal microflora performs a number of important functions to ensure the full functioning of the human body, namely: trophic, protective, metabolic, vitamin-forming, endocrine, anti-mutagenic and anti-carcinogenic functions in addition to effects on brain function and behavioral reactions [16,25,32,36,38,40,52,53,54].…”

Section: Human Microbiotamentioning

confidence: 99%

“…It was shown that a decrease in pH in the intestinal lumen inhibits the growth of bacteroids, clostridia and E. coli, but does not affect bifidobacteria [6]. Bifidobacteria, producing acetic and lactic acids, inhibit the growth of pathogenic strains, in particular E. coli and Clostridium [6,32].…”

Section: Risk Factors For the Development Of Allergy Associated Withmentioning

confidence: 99%

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The role of microbiota in the development of allergic diseases

Boyarchuk¹,

CHORNOMYDZ²,

Chornomydz³

et al. 2019

hpc

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Scientific progress, industrial development, urbanization, and the "sterile" way of life have a significant negative side, namely, the sustained growth of allergic diseases. The "hygienic theory" is used to explain the unceasing increase in the incidence of allergies in the population. At the same time, an important link in the development of allergic diseases is the microbiological environment and our own microbiota. In our literature review we gathered new data on the pathogenetic relationships between the violation of the quantitative and qualitative composition of our microbiocenosis and the development of allergic diseases. The basic mechanisms by which microbiota influence the development of an allergic process have been established, in particular: influence on T-cell immunity, synthesis of cytokines, etc. In this review, particular attention is paid to factors that lead to microbiocenosis and contribute to the development of allergies. Among them it is worth to highlight inappropriate nutrition, "sterile" style of life, widespread using of antiseptics and antibiotics, etc. Therefore, the most important step in the prevention of allergic diseases is the modification of lifestyle, breastfeeding of children, frequent staying in the open air and contact with nature, rational use of antiseptics and antibiotics.

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Section: Human Microbiotamentioning

confidence: 99%

Section: Human Microbiotamentioning

confidence: 99%

Section: Human Microbiotamentioning

confidence: 99%

Section: Human Microbiotamentioning

confidence: 99%

Section: Risk Factors For the Development Of Allergy Associated Withmentioning

confidence: 99%

See 3 more Smart Citations

The role of microbiota in the development of allergic diseases

Boyarchuk¹,

CHORNOMYDZ²,

Chornomydz³

et al. 2019

hpc

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Microbiota-Gut-Brain Axis

Szablewski

2022

Comprehensive Gut Microbiota

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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications

Leustean

Ciocoiu

Sava

et al. 2018

Journal of Diabetes Research

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The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases—retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity. Microbes can be considered a complex endocrine system capable of ensuring the proper functioning of the body but are also responsible for the development of numerous pathologies (diabetes, coronary syndromes, peripheral arterial disease, neoplasia, Alzheimer's disease, and hepatic steatosis). Changes in the intestinal microbiota may influence the host's sensitivity to insulin, body weight, and lipid and carbohydrate metabolism. Dysbiosis causes activation of proinflammatory mechanisms, metabolic toxicity, and insulin resistance. Trimethylamine N-oxide (TMAO) is a microbial organic compound generated by the large intestine, and its concentration increases in the blood after ingestion of foods rich in L-carnitine and choline, such as red meat, eggs, and fish. The interest for TMAO in cardiometabolic research has recently emerged, given the preclinical evidence that reveals a link between TMAO, diabetes, and cardiovascular complications. Intestinal microbiota can be modulated by changing one's lifestyle but also by antibiotic, probiotic, prebiotic, and fecal transplantation. The purpose of this article is to highlight issues related to the involvement of microbiota and trimethylamine N-oxide in the pathogenesis of diabetes mellitus and cardiovascular disease. Better appreciation of the interactions between food intake and intestinal floral-mediated metabolism can provide clinical insights into the definition of individuals with diabetic risk and cardiometabolic disease as well as potential therapeutic targets for reducing the risk of progression of the disease.

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Intestinal microbiota and its relationship with diabetes and obesity

Abstract: ABSTRACT

Cited by 12 publications

References 53 publications

The role of microbiota in the development of allergic diseases

The role of microbiota in the development of allergic diseases

Microbiota-Gut-Brain Axis

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications

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