Intestinal and multivisceral transplantation in children with severe gastrointestinal dysmotility

Intestinal transplantation for total intestinal aganglionosis: a series of 12 consecutive children

“…If we exclude multivisceral transplantation [16,17], there are few reports on the use of this type of colonic graft in ITx, along with a pull through, in HD [18]. As in our series of 43 ITx procedures with right colon grafting, the use of colon graft did not seem to be associated with a higher rate of complications, including infections and rejection [15].…”

Megacystis Megacolon Intestinal Hypoperistalsis Syndrome: A Rare Entity!

“…However hope for an improved outcome lies in multi-visceral transplantation for this condition; as has been reported for MMIHS [17]. The bladder function may still require intermittent catherization.…”

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome: Case Reports and Discussion of the Literature

“…Most children with MMIHS require repeated surgical diversion of bowel, enterostomies for nutrition and for relief of the bowel obstruction, but intestinal function does not usually improve after surgical manipulations and functional obstruction frequently recurs [19,20]. Currently, intestinal and multivisceral transplantation appears to be the only viable therapeutic alternative for children with severe gastrointestinal dysmotility [21]. …”

“…In other cases that required intestinal transplantation for reasons other than MMIHS, isolated intestinal transplantation before liver failure has developed has shown better outcomes such as earlier enteral feeding, when compared to multivisceral transplantation [23,24]. A series has reported 50% survival 3 years after intestinal and multivisceral transplantation, all survivors showed satisfactory gastric emptying and tolerated enteral feeds [21]. However, data on long-term survival of MMIHS and complications after transplantation such as rejection is still lacking.…”