Intestinal absorption in experimental Salmonella enterocolitis in mice

Disaccharide Hydrolysis, Intestinal Absorption and Electrogenic Properties in Salmonella Enterocolitis in Mice

“…chaco, the hydrolysis of maltose, sucrose or lactose yielded significantly lower monosaccharides compared to the untreated con trols. These results can be correlated with previous studies on the diseased mouse small intestine, when reduced levels of mucosal disaccharidases [13], extensive mucosal damage [12,14] and loss of absorptive capacity of mono saccharides [12, present work] were found.…”

“…Less fluid was generally transferred in the diseased intestine, particularly with sucrose. Using everted in vitro seg ments of the infected mouse intestine, either with or without glucose, the total fluid transfer fell proximally but rose distally, where the glucose-dependent mechanism increased, unlike the normal distal intestine, when the glucose-independent mechanism was more important [12].…”

“…chaco. sus pended in 0.3 ml saline, followed by an intraperitoneal injection of morphine sulphate (5 mg/mousc) to arrest intestinal peristalsis, thus allowing proliferation of the bacteria in the intestinal lumen, and the food returned (morphine does not affect absorption [12]). The infected animals were used 3 days later, after overnight starvation.…”

Disaccharide Hydrolysis, Intestinal Absorption and Electrogenic Properties in Salmonella Enterocolitis in Mice

“…chaco, the hydrolysis of maltose, sucrose or lactose yielded significantly lower monosaccharides compared to the untreated con trols. These results can be correlated with previous studies on the diseased mouse small intestine, when reduced levels of mucosal disaccharidases [13], extensive mucosal damage [12,14] and loss of absorptive capacity of mono saccharides [12, present work] were found.…”

“…Less fluid was generally transferred in the diseased intestine, particularly with sucrose. Using everted in vitro seg ments of the infected mouse intestine, either with or without glucose, the total fluid transfer fell proximally but rose distally, where the glucose-dependent mechanism increased, unlike the normal distal intestine, when the glucose-independent mechanism was more important [12].…”

“…chaco. sus pended in 0.3 ml saline, followed by an intraperitoneal injection of morphine sulphate (5 mg/mousc) to arrest intestinal peristalsis, thus allowing proliferation of the bacteria in the intestinal lumen, and the food returned (morphine does not affect absorption [12]). The infected animals were used 3 days later, after overnight starvation.…”

Bacillus cereus-Induced Malabsorption in Young Mice

“…The effects of B. cereus on intestinal absorption and fluid transfer in mice and those using Salmonella enteritidis (8) and Shigella dysenteriae and Shigella flexneri (10) were all broadly alike. However, malabsorption and decreased fluid transfer were more pronounced in experimental salmonellosis and shigellosis, and damage to the intestinal tissues and other effects in salmonellosis were more pronounced (11 13) than those observed using B. cereus.…”

Passage of Salmonella enteritidis and Salmonella thompson through chick ileocecal mucosa

“…The histological changes occurring during the invasion of mucosa by salmonellae and the host cellular response have been observed in humans (4), experimentally infected monkeys (6, 14), mice (1,11), guinea pigs (17), and chickens (20). One aspect of salmonella enterocolitis, however, that has received surprisingly little attention is that concerning the precise events which occur when salmonellae move from the intestinal lumen to the blood circulation.…”

Disaccharide Hydrolysis, Intestinal Absorption and Electrogenic Properties in Salmonella Enterocolitis in Mice

“…chaco, the hydrolysis of maltose, sucrose or lactose yielded significantly lower monosaccharides compared to the untreated con trols. These results can be correlated with previous studies on the diseased mouse small intestine, when reduced levels of mucosal disaccharidases [13], extensive mucosal damage [12,14] and loss of absorptive capacity of mono saccharides [12, present work] were found.…”

“…Less fluid was generally transferred in the diseased intestine, particularly with sucrose. Using everted in vitro seg ments of the infected mouse intestine, either with or without glucose, the total fluid transfer fell proximally but rose distally, where the glucose-dependent mechanism increased, unlike the normal distal intestine, when the glucose-independent mechanism was more important [12].…”

“…chaco. sus pended in 0.3 ml saline, followed by an intraperitoneal injection of morphine sulphate (5 mg/mousc) to arrest intestinal peristalsis, thus allowing proliferation of the bacteria in the intestinal lumen, and the food returned (morphine does not affect absorption [12]). The infected animals were used 3 days later, after overnight starvation.…”

Bacillus cereus-Induced Malabsorption in Young Mice

“…The effects of B. cereus on intestinal absorption and fluid transfer in mice and those using Salmonella enteritidis (8) and Shigella dysenteriae and Shigella flexneri (10) were all broadly alike. However, malabsorption and decreased fluid transfer were more pronounced in experimental salmonellosis and shigellosis, and damage to the intestinal tissues and other effects in salmonellosis were more pronounced (11 13) than those observed using B. cereus.…”

Passage of Salmonella enteritidis and Salmonella thompson through chick ileocecal mucosa

“…The histological changes occurring during the invasion of mucosa by salmonellae and the host cellular response have been observed in humans (4), experimentally infected monkeys (6, 14), mice (1,11), guinea pigs (17), and chickens (20). One aspect of salmonella enterocolitis, however, that has received surprisingly little attention is that concerning the precise events which occur when salmonellae move from the intestinal lumen to the blood circulation.…”

Disaccharide Hydrolysis, Intestinal Absorption and Electrogenic Properties in Salmonella Enterocolitis in Mice

“…chaco, the hydrolysis of maltose, sucrose or lactose yielded significantly lower monosaccharides compared to the untreated con trols. These results can be correlated with previous studies on the diseased mouse small intestine, when reduced levels of mucosal disaccharidases [13], extensive mucosal damage [12,14] and loss of absorptive capacity of mono saccharides [12, present work] were found.…”

“…Less fluid was generally transferred in the diseased intestine, particularly with sucrose. Using everted in vitro seg ments of the infected mouse intestine, either with or without glucose, the total fluid transfer fell proximally but rose distally, where the glucose-dependent mechanism increased, unlike the normal distal intestine, when the glucose-independent mechanism was more important [12].…”

“…chaco. sus pended in 0.3 ml saline, followed by an intraperitoneal injection of morphine sulphate (5 mg/mousc) to arrest intestinal peristalsis, thus allowing proliferation of the bacteria in the intestinal lumen, and the food returned (morphine does not affect absorption [12]). The infected animals were used 3 days later, after overnight starvation.…”

Bacillus cereus-Induced Malabsorption in Young Mice

“…The effects of B. cereus on intestinal absorption and fluid transfer in mice and those using Salmonella enteritidis (8) and Shigella dysenteriae and Shigella flexneri (10) were all broadly alike. However, malabsorption and decreased fluid transfer were more pronounced in experimental salmonellosis and shigellosis, and damage to the intestinal tissues and other effects in salmonellosis were more pronounced (11 13) than those observed using B. cereus.…”

Passage of Salmonella enteritidis and Salmonella thompson through chick ileocecal mucosa

“…The histological changes occurring during the invasion of mucosa by salmonellae and the host cellular response have been observed in humans (4), experimentally infected monkeys (6, 14), mice (1,11), guinea pigs (17), and chickens (20). One aspect of salmonella enterocolitis, however, that has received surprisingly little attention is that concerning the precise events which occur when salmonellae move from the intestinal lumen to the blood circulation.…”