Interventions for treating oral mucositis for patients with cancer receiving treatment

Abstract

Analysis 1.1. Comparison 1 benzydamine mouthwash versus placebo, Outcome 1 Improvement in mucositis.. .. Analysis 2.1. Comparison 2 low level laser versus sham, Outcome 1 Mild to moderate mucositis.. .. .. .. Analysis 3.1. Comparison 3 sucralfate versus placebo/salt and water/salt and soda, Outcome 1 Mucostis eradicated.. Analysis 4.1. Comparison 4 morphine (PCA) versus morphine (CI), Outcome 1 Average pain score.. .. .. . Analysis 4.2. Comparison 4 morphine (PCA) versus morphine (CI), Outcome 2 Daily mean opiate intake per hour. Analysis 4.3. Comparison 4 morphine (PCA) versus morphine (CI), Outcome 3 Duration of pain control.. .. .

Patient perceptions about chemotherapy-induced oral mucositis: implications for primary/secondary prophylaxis strategies

“…A Cochrane Systematic Review covering trials of topical and oral prophylactic agents for chemotherapy-induced OM has shown that only ice chips were marginally effective for OM, principally in short-acting chemotherapy agents/infusions such as fluorouracil [13]. The conclusion of another Cochrane Report in which all randomized controlled trials of agents for treatment of OM in patients receiving chemotherapy and/or radiation therapy were reviewed was that there is no strong evidence of efficacy for any particular agent [14].…”

Patient perceptions about chemotherapy-induced oral mucositis: implications for primary/secondary prophylaxis strategies

“…A Cochrane Systematic Review covering trials of topical and oral prophylactic agents for chemotherapy-induced OM has shown that only ice chips were marginally effective for OM, principally in short-acting chemotherapy agents/infusions such as fluorouracil [13]. The conclusion of another Cochrane Report in which all randomized controlled trials of agents for treatment of OM in patients receiving chemotherapy and/or radiation therapy were reviewed was that there is no strong evidence of efficacy for any particular agent [14].…”

Neutropenia Precautions for Children Receiving Chemotherapy or Stem Cell Transplantation for Cancer

“…Two commonly prescribed nonmedicated oral rinses were 0.9% saline or sodium bicarbonate mouth rinses 4 to 6 times per day (AAPD, 2013). A Cochrane review revealed several other interventions that proved to be beneficial to the prevention of mucositis; however, all of these interventions were recommended in adult patients (Clarkson, Worthington, Furness, McCabe, Khalid, Meyer, 2010). Three articles reviewed revealed the use of chlorhexidine as part of oral care protocols; however, systematic reviews show that chlorhexidine has little prophylactic effect on mucositis (AAPD, 2010; Glenny et al, 2010).…”

What is the Role of Pediatricians on Oral Health?

“…Mucositis invariably requires systemic analgesics, adjunctive medications, physical therapy and psychologic therapy in addition to oral care. A recent Cochrane review (Worthington, 2004) Pain from established mucositis can be reduced by systemic analgesics with non-steroidal agents and othernon-opiods used first, combined with opioids such as morphine and hydromorphone when pain is severe. In the in-patient setting, PCA provides the most effective pain control with lower total doses of opioid.…”

Patient perceptions about chemotherapy-induced oral mucositis: implications for primary/secondary prophylaxis strategies

“…A Cochrane Systematic Review covering trials of topical and oral prophylactic agents for chemotherapy-induced OM has shown that only ice chips were marginally effective for OM, principally in short-acting chemotherapy agents/infusions such as fluorouracil [13]. The conclusion of another Cochrane Report in which all randomized controlled trials of agents for treatment of OM in patients receiving chemotherapy and/or radiation therapy were reviewed was that there is no strong evidence of efficacy for any particular agent [14].…”

Neutropenia Precautions for Children Receiving Chemotherapy or Stem Cell Transplantation for Cancer

“…Two commonly prescribed nonmedicated oral rinses were 0.9% saline or sodium bicarbonate mouth rinses 4 to 6 times per day (AAPD, 2013). A Cochrane review revealed several other interventions that proved to be beneficial to the prevention of mucositis; however, all of these interventions were recommended in adult patients (Clarkson, Worthington, Furness, McCabe, Khalid, Meyer, 2010). Three articles reviewed revealed the use of chlorhexidine as part of oral care protocols; however, systematic reviews show that chlorhexidine has little prophylactic effect on mucositis (AAPD, 2010; Glenny et al, 2010).…”

What is the Role of Pediatricians on Oral Health?

“…Mucositis invariably requires systemic analgesics, adjunctive medications, physical therapy and psychologic therapy in addition to oral care. A recent Cochrane review (Worthington, 2004) Pain from established mucositis can be reduced by systemic analgesics with non-steroidal agents and othernon-opiods used first, combined with opioids such as morphine and hydromorphone when pain is severe. In the in-patient setting, PCA provides the most effective pain control with lower total doses of opioid.…”

Patient perceptions about chemotherapy-induced oral mucositis: implications for primary/secondary prophylaxis strategies

“…A Cochrane Systematic Review covering trials of topical and oral prophylactic agents for chemotherapy-induced OM has shown that only ice chips were marginally effective for OM, principally in short-acting chemotherapy agents/infusions such as fluorouracil [13]. The conclusion of another Cochrane Report in which all randomized controlled trials of agents for treatment of OM in patients receiving chemotherapy and/or radiation therapy were reviewed was that there is no strong evidence of efficacy for any particular agent [14].…”

Neutropenia Precautions for Children Receiving Chemotherapy or Stem Cell Transplantation for Cancer

“…Two commonly prescribed nonmedicated oral rinses were 0.9% saline or sodium bicarbonate mouth rinses 4 to 6 times per day (AAPD, 2013). A Cochrane review revealed several other interventions that proved to be beneficial to the prevention of mucositis; however, all of these interventions were recommended in adult patients (Clarkson, Worthington, Furness, McCabe, Khalid, Meyer, 2010). Three articles reviewed revealed the use of chlorhexidine as part of oral care protocols; however, systematic reviews show that chlorhexidine has little prophylactic effect on mucositis (AAPD, 2010; Glenny et al, 2010).…”

What is the Role of Pediatricians on Oral Health?

“…Mucositis invariably requires systemic analgesics, adjunctive medications, physical therapy and psychologic therapy in addition to oral care. A recent Cochrane review (Worthington, 2004) Pain from established mucositis can be reduced by systemic analgesics with non-steroidal agents and othernon-opiods used first, combined with opioids such as morphine and hydromorphone when pain is severe. In the in-patient setting, PCA provides the most effective pain control with lower total doses of opioid.…”